Synergistic Effects of Carbohydrate Polymers on the Performance of Hybrid Injectable Bone Pastes Publisher



Salehi G¹ ; Behnamghader A¹ ; Hesaraki S¹ ; Mozafari M^{1, 2, 3}
Source: European Polymer Journal Published:2019

Abstract

During the past few years, invasive surgery operations using injectable systems, have been applied for the treatment of osteoporosis bone defects. In this research, different injectable pastes made from natural polymer such as gelatin (Ge), carboxymethyl cellulose (CMC), alginate (Alg) and inorganic materials containing hydroxyapatite (HA) and biphasic calcium phosphate (BCP) were studied. BCP was fabricated via solid state reaction. Evaluation of BCP crystalline structure confirmed the presence of tricalcium phosphate (TCP) and HA phases. The morphology of calcium phosphate powders and the paste showed fine particles and homogeneous distribution, respectively. Consistency, injectability, washout and the rheology behavior of pastes were evaluated too. According to the results, the pastes consisted of considerable values of calcium phosphate content (about 65%) and injectability of 84% and 91% with acceptable degradation in PBS, were found for Gel/0.4% CMC and Gel/1.2% Alg pastes, respectively. It could be concluded that the addition of carbohydrate polymers (CMC and Alg) to the formulation of samples could be an effective way to adjust the final performance of the hybrid injectable bone pastes. © 2019 Elsevier Ltd