Investigating the Relationship Between Insulin Resistance and Adipose Tissue in a Randomized Tehrani Population Publisher Pubmed



Mirzay Razzaz J¹ ; Moameri H² ; Akbarzadeh Z³ ; Ariya M⁴ ; Hosseini SA⁵ ; Ghaemi A⁶ ; Osati S¹ ; Ehrampoush E^{4, 7} ; Homayounfar R^{1, 4}
Source: Hormone Molecular Biology and Clinical Investigation Published:2021

Abstract

Objectives: Insulin resistance is the most common metabolic change associated with obesity. The present study aimed to investigate the relationship between insulin resistance and body composition especially adipose tissue in a randomized Tehrani population. Methods: This study used data of 2,160 individuals registered in a cross-sectional study on were randomly selected from among subjects who were referred to nutrition counseling clinic in Tehran, from April 2016 to September 2017. Insulin resistance was calculated by homeostasis model assessment formula. The odds ratio (95% CI) was calculated using logistic regression models. Results: The mean age of the men was 39 (±10) and women were 41 (±11) (the age ranged from 20 to 50 years). The risk of increased HOMA-IR was 1.03 (95% CI: 1.01-1.04) for an increase in one percent of Body fat, and 1.03 (95% CI: 1.00-1.05) for an increase in one percent of Trunk fat. Moreover, the odds ratio of FBS for an increase in one unit of Body fat percent and Trunk fat percent increased by 1.05 (adjusted odds ratio [95% CI: 1.03, 1.06]) and 1.05 (95% CI: 1.02, 1.08). Also, the risk of increased Fasting Insulin was 1.05 (95% CI: 1.03-1.07) for an increase in one unit of Body fat percent, and 1.05 (95% CI: 1.02-1.08) for an increase in one unit of Trunk fat percent. Conclusions: The findings of the present study showed that there was a significant relationship between HOMA-IR, Fasting blood sugar, Fasting Insulin, and 2 h Insulin with percent of Body fat, percent of Trunk fat. © 2021 Walter de Gruyter GmbH, Berlin/Boston.