Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Limitations in Clinical Translation of Nanoparticle-Based Gene Therapy Publisher Pubmed



Wong JKL1 ; Mohseni R2 ; Hamidieh AA2 ; Maclaren RE3 ; Habib N4 ; Seifalian AM5
Authors

Source: Trends in Biotechnology Published:2017


Abstract

Organic nanoparticle-based (ONP) gene therapy is a potential strategy to cure human cancer. However, there are still many practical barriers before the promising results from in vitro and preclinical studies can be translated to clinical success. We discuss the reasons behind the hesitant uptake by the clinic. © 2017 Elsevier Ltd
Related Docs
View other Related Docs
1. Will Nanotechnology Bring New Hope for Gene Delivery?, Trends in Biotechnology (2017)
2. Gene Therapy Clinical Trials, Where Do We Go? an Overview, Biomedicine and Pharmacotherapy (2022)
3. Nanovehicles for Co-Delivery of Anticancer Agents, Drug Discovery Today (2020)
Experts (# of related papers)
View all Related Experts
Fatemeh Atyabi (3)
Ali Abbasi (1)
Other Related Docs
4. Clinical Applications of Nanomedicine in Cancer Therapy, Drug Discovery Today (2020)
5. Recent Advances in Gene Therapy-Based Cancer Monotherapy and Synergistic Bimodal Therapy Using Upconversion Nanoparticles: Structural and Biological Aspects, Biomedicine and Pharmacotherapy (2022)
6. Functionalised Nanomaterials for Eradication of Cscs, a Promising Approach for Overcoming Tumour Heterogeneity, Journal of Drug Targeting (2018)
7. Nanocellulose-Based Delivery Systems and Cervical Cancer: Review of the Literature, Current Pharmaceutical Design (2021)
8. A Concise Review on Cancer Treatment Methods and Delivery Systems, Journal of Drug Delivery Science and Technology (2019)
9. New Insights Into Designing Hybrid Nanoparticles for Lung Cancer: Diagnosis and Treatment, Journal of Controlled Release (2019)
10. Nano-Particles’ Benefits for Colon Cancer Effective Therapy: A Review of Recent Advancements and Clinical Trials, International Journal of Polymeric Materials and Polymeric Biomaterials (2024)
11. Nanoimmunoengineering Strategies in Cancer Diagnosis and Therapy, Clinical and Translational Oncology (2023)
12. Gene Therapy: A Promising Approach for Breast Cancer Treatment, Cell Biochemistry and Function (2022)
13. Chitosan-Based Smart Stimuli-Responsive Nanoparticles for Gene Delivery and Gene Therapy: Recent Progresses on Cancer Therapy, International Journal of Biological Macromolecules (2024)
14. Nanoparticle-Sirna: A Potential Strategy for Ovarian Cancer Therapy?, Nanomedicine (2019)
15. Nano-Biotechnology and Challenges of Drug Delivery System in Cancer Treatment Pathway: Review Article, Chemistry and Biodiversity (2023)
16. Nanoparticles in Cancer Theranostics: Focus on Gliomas, BioNanoScience (2025)
17. A Review of Dna Nanoparticles-Encapsulated Drug/Gene/Protein for Advanced Controlled Drug Release: Current Status and Future Perspective Over Emerging Therapy Approaches, International Journal of Biological Macromolecules (2024)
18. Encapsulation for General Cancer Treatment, Principles of Biomaterials Encapsulation: Volume 2 (2023)
19. Cancer Nanomedicine: Special Focus on Cancer Immunotherapy, Cancer Immunology: Bench to Bedside Immunotherapy of Cancers# Second Edition (2020)
20. In Vitro and in Vivo Evaluation of Therapy Targeting Epithelial-Cell Adhesion-Molecule Aptamers for Non-Small Cell Lung Cancer, Journal of Controlled Release (2015)