Treatment of Resistant Visceral Leishmaniasis With Interferon Gamma in Combination With Liposomal Amphotericin B and Allopurinol Publisher Pubmed



Khodabandeh M¹ ; Rostami A² ; Borhani K¹ ; Gamble HR³ ; Mohammadi M⁴
Source: Parasitology International Published:2019

Abstract

This report describes the first case of visceral leishmaniasis (VL)resistant to pentavalent antimonials and also the first use of combinational therapy in Iran. The patient was a two-year old boy, from a non-endemic area for leishmaniasis in northern Iran, presenting with pentavalent antimonial resistant VL. Additional treatment with conventional and liposomal amphotericin B was not effective. A complete cure was achieved following a three week treatment with liposomal amphotericin B (5 mg/kg/day for 5 days, then on the 14th and 21st days), allopurinol (25 mg/day for 5 days, then on the 14th and 21st days)and interferon gamma (50 μg/m2 subcutaneously three times weekly). Our results suggest a need for further studies to identify resistant Leishmania species and their susceptibility to different treatment regimens. © 2019 Elsevier B.V.