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Facile Fabrication and Characterization of a Novel Oral Ph-Sensitive Drug Delivery System Based on Cmc Hydrogel and Hnt-At Nanohybrid Publisher Pubmed



Hossieniaghdam SJ1 ; Foroughinia B2 ; Zareakbari Z3 ; Mojaradjabali S4 ; Motasadizadeh H5 ; Farhadnejad H6
Authors

Source: International Journal of Biological Macromolecules Published:2018


Abstract

The main aim of the present study was to design pH-sensitive bionanocomposite hydrogel beads based on CMC and HNT-AT nanohybrid and evaluate whether prepared bionanocomposite beads have the potential to be used in drug delivery applications. Atenolol (AT), as a model drug, was incorporated into the lumen of HA nanotubes via the co-precipitation technique. HNT/AT nanohybrid and CMC/HNT-AT beads were characterized via XRD, SEM, TGA, and FT-IR techniques. Drug loading and encapsulation efficiency was found to be high for CMC/HNT3 beads. Moreover, the swelling and drug release properties of the prepared CMC/HA-AT beads were investigated, and showed a pH sensitive swelling behavior with maximum its content at pH 6.8. Also, it was found that the swelling ratio of CMC/HNT beads was lower than that of pristine CMC beads. Drug release behavior of CMC/HNT-AT bionanocomposite hydrogel beads were investigated. A more sustained and controlled drug releases were observed for CMC/HNT-AT beads. © 2017 Elsevier B.V.
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