Microfluidic-Engineered Polymeric Nanocarriers for Targeted Drug Delivery in Liver Cancer Therapy: Part Ii Recent Advances Publisher Pubmed



Ebrahimiverkiani A ; Ebrahimi Varkiani M ; Jadid Tavaf M ; Naghib SM ; Rabiee N
Source: Expert Opinion on Drug Delivery Published:2026

Abstract

Introduction: Conventional drug delivery systems in cancer therapy face limitations such as poor targeting and adverse side effects. Nanoparticle-based approaches, particularly when integrated with microfluidic technology, have emerged as promising strategies to improve therapeutic precision and outcomes, especially in liver cancer treatment. Areas covered: This review discusses recent progress in the use of nanoparticles and polymers for targeted drug delivery, highlighting their ability to encapsulate therapeutic agents and release them at specific sites. The role of microfluidic platforms in drug loading is emphasized, as they enable precise manipulation at micro- and nanoscale levels with minimal sample loss. Literature examining the use of polymer-based nanocarriers, microfluidic-assisted drug encapsulation, and their applications in overcoming tumor growth and liver cancer therapy is analyzed. The article also explores the advantages of microfluidics as a tool for fabricating complex nanosystems for controlled and efficient delivery. Expert opinion: Microfluidic-assisted nanoparticle delivery represents a highly promising approach for advancing liver cancer treatment. With its potential to support combination therapies and enable intricate, customizable nanosystems, this platform is likely to shape the future of targeted cancer therapeutics. © 2025 Informa UK Limited, trading as Taylor & Francis Group.