Direct Immunofluorescence Results of the Skin Biopsy and Frequency of Systemic Involvement in Children With Henoch-Schonlein Purpura Publisher Pubmed



Ataeepour M¹ ; Monajemzadeh M^{2, 3} ; Sadeghi P⁴ ; Ziaee V^{2, 4, 5}
Source: Fetal and Pediatric Pathology Published:2019

Abstract

Objective: Henoch-Schonlein purpura (HSP) is a common vasculitis in children that can present with multi-organ involvement. The aim of this study is to investigate the correlation between direct immunofluorescence (DIF) results and the systemic involvements of the HSP in pediatric patients. Material and Methods: Those HSP patients with leukocytoclastic vasculitis on their biopsies who also had documented immunoglobulin/complement deposition by DIF were included in our study. Their demographic and laboratory data and clinical manifestations were recorded and analyzed. Results: Medical records of 95 patients (1.5–15 years old) were studied. 26.3% of the patients showed renal, 86.3% articular, and 70.3% gastrointestinal involvement. The risk of renal involvement was significantly higher in those with C3 deposition in their skin DIF. IgM deposition was mostly associated with articular involvement. Conclusion: Pediatric HSP patients who had C3 deposition in their skin DIF should be selected for further evaluation regarding HSP nephritis. © 2018, © 2018 Taylor & Francis Group, LLC.