Serum Dkk1 Is Correlated With Γ Peak of Serum Electrophoresis in Multiple Myeloma: A Multicenter Biomarker Study Publisher Pubmed



Hashemi ZS¹ ; Khalili S^{2, 3} ; Malaei F² ; Mardsoltani M⁴ ; Jafarisani M⁵ ; Lotfi J⁶ ; Deemeh MR⁶ ; Zakeri A³ ; Rasaee MJ²
Source: Biomarkers in Medicine Published:2019

Abstract

Aim: DKK1 is reported to be produced at high levels by myeloma cells. Therefore, the applicability of DKK1 as a tumor marker for multiple myeloma (MM) diagnosis was examined. Methods: Serum samples were collected and analyzed by DKK1 concentration kit and capillary zone electrophoresis. Then, the obtained results were statically analyzed. Results: It has been determined that the 10 ng/ml of DKK1 is the optimal level for MM diagnosis. Moreover, there was an ascending linear correlation between the DKK1 concentration and γpeak. Discussion: The observed correlation could be rooted in the positive feedback loop between MM cells and the mesenchymal stem cells. In view of these results, DKK1 could be deemed as diagnostic marker for MM. © 2019 Future Medicine Ltd.