Correlation Between Electrodiagnostic Findings and Cerebrospinal Fluid Changes in Children With Guillain-Barre Syndrome Publisher



Noory M¹ ; Eftekhari K² ; Shabanimirzaee H³ ; Barzegar M⁴ ; Malekiantaghi A⁵
Source: Iranian Journal of Child Neurology Published:2025

Abstract

Objectives Guillain-Barre syndrome (GBS) involves the peripheral nervous system developed by infections or immune conditions. Cerebrospinal fluid (CSF) analysis and electrodiagnostic tests are essential diagnostic methods for GBS. However, limited data are available on how the findings from these methods relate to each other. This study aimed to evaluate changes in CSF analysis and electrodiagnostic tests in pediatrics with GBS. Materials & Methods The present study retrospectively evaluated electrodiagnostic tests and CSF changes in pediatrics with GBS who were admitted to Tabriz Hospital, Iran, from 2010 to 2020 due to CBS. Patients’ data, including age, gender, CSF analysis, and electrodiagnostic test results, were recorded from the patients’ files. Electrodiagnostic data included pace and amplitude of tibial, median, peroneal, sural, ulnar nerves, nerve conduction velocity (NCV), F-wave, and motor unit action potential (MUAP). The significance level was considered less than 0.05. Results The mean age of patients was 4.83±2.72 years, and 54.6% were boys. The most common type of GBS involvement was demyelinating type. No gender differences were found between involved nerves unless the ulnar nerve was significantly more involved in girls (P-value: 0.012). The obtained findings indicated no significant relationship between electrodiagnostic tests and CSF protein (P-value: 0.439). Conclusion No association was observed between electrodiagnostic results and CSF changes in pediatrics with GBS. © 2025 The Authors.