Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Blockade of P75 Neurotrophin Receptor Reverses Irritability and Anxiety-Related Behaviors in a Rat Model of Status Epilepticus Publisher Pubmed



Mehrabi S1 ; Janahamdi M2 ; Joghataie MT1, 4, 5 ; Barati M3 ; Marzban M1 ; Hadjighassem M1, 6 ; Farahmandfar M1
Authors

Source: Iranian Biomedical Journal Published:2018


Abstract

Background: Many recent epidemiological studies have shown that epileptic patients are more likely suffer from depression, anxiety, and irritability. However, the cellular mechanisms of epilepsy-induced psychotic behaviors are not fully elucidated. Neurotrophin receptors have been suggested to be involved in epilepsy and also in psychiatric disorders. Up-regulation of p75NTR expression and activation of p75NTR signalling cascades after the seizure have been shown, but the role of the p75 receptor in epilepsy-induced psychotic behaviors has not been documented so far. Therefore, the present work aimed to investigate the effect of p75 receptor blockade on seizure activity, irritability, and anxiety-like behaviors in a rat model of status epilepticus. Methods: Rats were injected with pilocarpine (350 mg/ kg, i.p.) to induce status epilepticus. Then various behavioral tests were performed after the blockade of p75NTR alone or in combination with p75 antagonist and phenobarbital. Molecular analysis by PCR was performed to investigate the expression of p75 and pro-NGF. Results: Molecular findings indicated a high level of mRNA expression for both p75 receptors and pro-NGF in the epileptic model group. Results also showed that the administration of p75 antagonist alone or in combination with phenobarbital was able to significantly influence the behavioral responses. Furthermore, 20-hours video monitoring showed a decrease in the frequency and duration of seizures in the rat group receiving p75 antagonist. Conclusion: Taken together, the present study suggests that the blockade of the p75 receptor may affect the irritability and anxiety-related behavior in a rat model of status epilepticus. © 2018, Pasteur Institute of Iran. All rights reserved.
Related Docs
View other Related Docs
1. Research Paper: Effect of Co-Administration of Bumetanide and Phenobarbital on Seizure Attacks in Temporal Lobe Epilepsy, Basic and Clinical Neuroscience (2018)
2. Evaluation of Metformin Effects in the Chronic Phase of Spontaneous Seizures in Pilocarpine Model of Temporal Lobe Epilepsy, Metabolic Brain Disease (2018)
3. Comparison of Intranasal and Intraperitoneal Administration of Eugenia Caryophyllata (Clove) Essential Oil on Spatial Memory, Anxiety-Like Behavior and Locomotor Activity in a Pilocarpine-Induced Status Epilepticus Rat Model, BMC Complementary Medicine and Therapies (2022)
Experts (# of related papers)
View all Related Experts
Ahmad Reza Dehpour (10)
Mahmoud Reza Hadjighassem (3)
Other Related Docs
4. Brain Derived Neurotrophic Factor Modification of Epileptiform Burst Discharges in a Temporal Lobe Epilepsy Model, Basic and Clinical Neuroscience (2016)
5. Psychogenic Non-Epileptic Seizures; a Narrative Review, Archives of Academic Emergency Medicine (2020)
6. Assessment of the Protective Effect of Kn-93 Drug in Systemic Epilepsy Disorders Induced by Pilocarpine in Male Rat, Journal of Cellular Biochemistry (2019)
7. Effects of Onopordia, a Novel Isolated Compound From Onopordon Acanthium, on Pentylenetetrazole-Induced Seizures in Mice: Possible Involvement of Nitric Oxide Pathway, Journal of Traditional and Complementary Medicine (2021)
8. Sumatriptan Reduces Severity of Status Epilepticus Induced by Lithium–Pilocarpine Through Nitrergic Transmission and 5-Ht1b/D Receptors in Rats: A Pharmacological-Based Evidence, Fundamental and Clinical Pharmacology (2021)
9. Evidence for Additionally Increased Apoptosis in the Peripheral Blood Mononuclear Cells of Major Depressive Patients With a High Risk for Suicide, American Journal of Medical Genetics# Part B: Neuropsychiatric Genetics (2018)
10. Involvement of Nitrergic System in Anticonvulsant Effect of Zolpidem in Lithium-Pilocarpine Induced Status Epilepticus: Evaluation of Inos and Cox-2 Genes Expression, European Journal of Pharmacology (2017)
11. Modulatory Effect of Opioid Ligands on Status Epilepticus and the Role of Nitric Oxide Pathway, Epilepsy and Behavior (2019)
12. The Possible Role of Nitric Oxide in Anti-Convulsant Effects of Naltrindole in Seizure-Induced by Social Isolation Stress in Male Mice, Biomedicine and Pharmacotherapy (2020)
13. Involvement of Ppar Receptors in the Anticonvulsant Effects of a Cannabinoid Agonist, Win 55,212-2, Progress in Neuro-Psychopharmacology and Biological Psychiatry (2015)
14. The Blockade of Transient Receptor Potential Ankyrin 1 (Trpa1) Protects Against Ptz-Induced Seizure, Metabolic Brain Disease (2023)
15. Effects of Trpv1 on the Hippocampal Synaptic Plasticity in the Epileptic Rat Brain, Synapse (2015)
16. Nmda Receptor Antagonists Attenuate the Proconvulsant Effect of Juvenile Social Isolation in Male Mice, Brain Research Bulletin (2016)
17. Chronically Altered Nmdar Signaling in Epilepsy Mediates Comorbid Depression, Acta Neuropathologica Communications (2021)
18. Trpv1 Receptors Augment Basal Synaptic Transmission in Ca1 and Ca3 Pyramidal Neurons in Epilepsy, Neuroscience (2016)
19. Psilocin, a Psychedelic Drug, Exerts Anticonvulsant Effects Against Ptz- and Mes-Induced Seizures in Mice Via 5-Ht1a and Cb1 Receptors: Involvement of Nitrergic, Opioidergic, and Kynurenine Pathways, Pharmacology Research and Perspectives (2025)
20. Pentylenetetrazole Preconditioning Attenuates Severity of Status Epilepticus Induced by Lithium-Pilocarpine in Male Rats: Evaluation of Opioid/Nmda Receptors and Nitric Oxide Pathway, Pharmacological Reports (2022)