Association of Neutrophil to Lymphocyte Ratio With Bone Mineral Density in Post-Menopausal Women: A Systematic Review and Meta-Analysis Publisher Pubmed



Salimi M¹ ; Khanzadeh M² ; Nabipoorashrafi SA⁴ ; Seyedi SA⁴ ; Yaghoobpoor S⁵ ; Brismee JM⁶ ; Luckewold B⁷ ; Ebadi M⁸ ; Ghaedi A⁹ ; Kumar VS¹⁰ ; Mirghaderi P¹¹ ; Rabie H¹² ; Khanzadeh S¹³
Source: BMC Women's Health Published:2024

Abstract

Background: We conducted a systematic review and meta-analysis to compare the neutrophil lymphocyte ratio (NLR) levels between women with post-menopausal osteopenia or osteoporosis to those with normal bone mineral density (BMD). Methods: We used Web of Science, PubMed, and Scopus to conduct a systematic search for relevant publications published before June 19, 2022, only in English language. We reported standardized mean difference (SMD) with a 95% confidence interval (CI). Because a significant level of heterogeneity was found, we used the random-effects model to calculate pooled effects. We used the Newcastle–Ottawa scale for quality assessment. Results: Overall, eight articles were included in the analysis. Post-menopausal women with osteoporosis had elevated levels of NLR compared to those without osteoporosis (SMD = 1.03, 95% CI = 0.18 to 1.88, p = 0.017, I2 = 98%). In addition, there was no difference between post-menopausal women with osteopenia and those without osteopenia in neutrophil lymphocyte ratio (NLR) levels (SMD = 0.58, 95% CI=-0.08 to 1.25, p = 0.085, I2 = 96.8%). However, there was no difference between post-menopausal women with osteoporosis and those with osteopenia in NLR levels (SMD = 0.75, 95% CI=-0.01 to 1.51, p = 0.05, I2 = 97.5%, random-effect model). Conclusion: The results of this study point to NLR as a potential biomarker that may be easily introduced into clinical settings to help predict and prevent post-menopausal osteoporosis. © The Author(s) 2024.