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Inherited Interleukin 2-Inducible T-Cell (Itk) Kinase Deficiency in Siblings With Epidermodysplasia Verruciformis and Hodgkin Lymphoma Publisher Pubmed



Youssefian L1, 2 ; Vahidnezhad H1, 4 ; Yousefi M5, 6 ; Saeidian AH1 ; Azizpour A7 ; Touati A1, 8 ; Nikbakht N1 ; Hesari KK9 ; Adibsereshki MM10 ; Zeinali S4, 11 ; Mansoori B12, 13 ; Jazayeri A14 ; Karamzadeh R15 ; Fortina P16 Show All Authors
Authors
  1. Youssefian L1, 2
  2. Vahidnezhad H1, 4
  3. Yousefi M5, 6
  4. Saeidian AH1
  5. Azizpour A7
  6. Touati A1, 8
  7. Nikbakht N1
  8. Hesari KK9
  9. Adibsereshki MM10
  10. Zeinali S4, 11
  11. Mansoori B12, 13
  12. Jazayeri A14
  13. Karamzadeh R15
  14. Fortina P16
  15. Jouanguy E17, 18, 19
  16. Casanova JL17, 18, 19, 20, 21
  17. Uitto J1

Source: Clinical Infectious Diseases Published:2019


Abstract

Biallelic mutations in the ITK gene cause a T-cell primary immunodeficiency with Epstein-Barr virus (EBV)-lymphoproliferative disorders. We describe a novel association of a homozygous ITK mutation with β-human papillomavirus (HPV)-positive epidermodysplasia verruciformis. Thus, loss of function in ITK can result in broad dysregulation of T-cell responses to oncogenic viruses, including β-HPV and EBV. © The Author(s) 2018. Published by Oxford University Press for the Infectious Diseases Society of America. All rights reserved.
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