Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Anxiolytic and Antidepressant Effects of Cytocholine and Clozapine on Adult Female Mice



Ghalandarishamami M1 ; Khakpai F1 ; Zarrindast MR2
Authors

Source: Koomesh Published:2023

Abstract

Introduction: Anxiety and depression are associated with significant functional disabilities. It seems that use new drugs that can increase the effectiveness of antidepressants and anti-anxiety drugs. Citicoline and clozapine are used as effective chemical agents to improve the symptoms of some neurological diseases. Materials and Methods: 40 adult female mice were used in this study, clozapine (0.5 and 1 mg/ml) and cytocholine with doses of 50 and 100 mg/ml were injected intraperitoneally. Then the elevated plus-maze (EPM) and forced swimming test (FST), respectively conducted to evaluate anxiety and depression symptoms. Results: The results showed that only citicoline at a dose of 100 mg/ml could reduce depressive behaviors in the FST test, but clozapine did not change antidepressant and anti-anxiety behaviors compared to the control group. Conclusion: Based on the results, it can be concluded Citicoline administration as a drug by activating the dopaminergic system has more significant effects in reducing depression like behaviors. © 2023, Semnan University of Medical Sciences. All rights reserved.
Related Docs
View other Related Docs
1. Effect of Citicoline and Transcranial Direct Current Stimulation on Depressive-Like Behaviors in Mice & Quot, Behavioural Brain Research (2023)
2. Combined Treatment of Scopolamine and Group Iii Mglur Antagonist, Cppg, Exerts Antidepressant Activity Without Affecting Anxiety-Related Behaviors, Physiology and Behavior (2020)
3. The Effect of Nicotine on Antidepressant and Anxiolytic Responses Induced by Citalopram and Citicoline in Mice, Acta Neurobiologiae Experimentalis (2023)
Experts (# of related papers)
View all Related Experts
Shahin Akhondzadeh Basti (2)
Maryam Tabatabaee (1)
Other Related Docs
4. Preclinical Evidence for the Anxiolytic- and Antidepressant-Like Effects of Citicoline and Imipramine in the Sciatic Nerve-Ligated Mice, IBRO Neuroscience Reports (2024)
5. Isobolographic Analysis of the Antidepressant Interaction in Two-Drug Combinations of Citalopram, Bupropion, and Scopolamine in Mice, Naunyn-Schmiedeberg's Archives of Pharmacology (2022)
6. Interaction Between Citalopram and Omega-3 Fatty Acids on Anxiety and Depression Behaviors and Maintaining the Stability of Brain Pyramidal Neurons in Mice, Neuroscience Letters (2024)
7. The Combination of Citalopram and Crocin Synergistically Alleviates the Anxiogenic-Related Behaviors Induced by Acute Restraint Stress (Ars) in Male Mice, Physiology and Behavior (2025)
8. Additive Interaction Between Scopolamine and Nitric Oxide Agents on Immobility in the Forced Swim Test But Not Exploratory Activity in the Hole-Board, Psychopharmacology (2019)
9. Synergistic Effect Between Imipramine and Citicoline Upon Induction of Analgesic and Antidepressant Effects in Mice, Neuroscience Letters (2021)
10. Influence of Citicoline on Citalopram-Induced Antidepressant Activity in Depressive-Like Symptoms in Male Mice, Physiology and Behavior (2018)
11. Comparative Assessment of Antidepressant-Related Behaviors of Citalopram, Crocin, and Their Combination in Non-Acute Restraint Stress and Acute Restraint Stress Mice, IBRO Neuroscience Reports (2025)
12. Synergistic Antidepressant- and Anxiolytic-Like Effects of Harmaline Along With Cinanserin in Acute Restraint Stress-Treated Mice, Psychopharmacology (2021)
13. Citicoline (Cdp-Choline) Add-On Therapy to Risperidone for Treatment of Negative Symptoms in Patients With Stable Schizophrenia: A Double-Blind, Randomized Placebo-Controlled Trial, Human Psychopharmacology (2018)
14. Synergistic Effect Between Citalopram and Muscimol Upon Induction of Anxiolytic- and Antidepressant-Like Effects in Male Mice: An Isobologram Analysis, IBRO Neuroscience Reports (2024)
15. Selective Serotonin Reuptake Inhibitors in Major Depression Disorder Treatment: An Umbrella Review on Systematic Reviews, International Journal of Psychiatry in Clinical Practice (2020)
16. The Role of Nitric Oxide–Cgmp Pathway in Selegiline Antidepressant-Like Effect in the Mice Forced Swim Test, Pharmacological Reports (2018)
17. Additive Anxiolytic-Like Effect of Citicoline and Acpa in the Non-Acute Restraint Stress (Nars) and Acute Restraint Stress (Ars) Mice, Physiology and Behavior (2024)
18. Ketamine-Induced Antidepressant Like Effects in Mice: A Possible Involvement of Cannabinoid System, Biomedicine and Pharmacotherapy (2019)
19. Synergistic Effect Between Quinpirole and L-Name As Well As Sulpiride and L-Arginine on the Modulation of Anxiety and Memory Processes in the 6-Ohda Mouse Model of Parkinson's Disease: An Isobologram Analysis, Neurobiology of Learning and Memory (2021)
20. Gaba-Ergic Agents Modulated the Effects of Histamine on the Behaviour of Male Mice in the Elevated Plus Maze Test, Experimental Physiology (2022)