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Six New Triterpenoids From the Root of Potentilla Reptans and Their Cardioprotective Effects in Silico Publisher Pubmed



Enayati A1, 2 ; Salehi A1 ; Alilou M3 ; Stuppner H3 ; Mirzaei H1 ; Omraninava A2 ; Khori V1 ; Yassa N2
Authors

Source: Natural Product Research Published:2022


Abstract

Tormentic acid ester glucosides derivatives (1, 2 and 4), 3-oxoursane ester glycoside (3) and 11-methoxy-ursane ester glycosides (5, 6) as six new triterpenoids, along with catechin were isolated from the ethyl acetate fraction of Potentilla reptans root (Et) methanolic extract. The structures of the compounds were elucidated by 1D, 2D NMR, IR and MS spectroscopy. Additionally, isolated triterpenoid compounds (1–6) and catechin were evaluated for their cardioprotective effects via glycogen synthase kinase 3β (GSK-3β) and glucocorticoid regulated kinase-1 (SGK1) protein kinase inhibition by Molecular Docking. Compound 1 and catechin (compound 7) exhibited significant inhibitory effects against GSK-3β and SGK1 protein kinases with a binding energy value −9.1 and −8.8 kcal/mol, respectively. Hence, Et can be a suitable natural candidate to protect cardiomyocytes injury. © 2021 Informa UK Limited, trading as Taylor & Francis Group.
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