Evaluation of Antimicrobial Properties of Conventional Poly(Methyl Methacrylate) Denture Base Resin Materials Containing Hydrothermally Synthesised Anatase Tio2 Nanotubes Against Cariogenic Bacteria and Candida Albicans



Naji SA^{1, 2} ; Kashi TSJ^{3, 4} ; Pourhajibagher M^{4, 5, 6} ; Behroozibakhsh M^{3, 7} ; Masaeli R^{3, 7} ; Bahador A^{4, 6}
Source: Iranian Journal of Pharmaceutical Research Published:2018

Abstract

The purpose of this study was to investigate the antimicrobial properties of a conventional poly methyl methacrylate (PMMA) modified with hydrothermally synthesised titanium dioxide nanotubes (TNTs). Minimum inhibitory concentration (MIC), minimum bactericidal concentration (MBC), and minimum fungicidal concentrations (MFC) for planktonic cells of the TiO2 nanotubes solution against Lactobacillus acidophilus, Streptococcus mutans and Candida albicans were determined. The powder of conventional acrylic resin was modified using 2.5% and 5% by weight synthesised titanium dioxide (TiO2) nanotubes, and rectangular-shaped specimens (10 mm × 10 mm × 3 mm) were fabricated. The antimicrobial properties of ultraviolet (UV) and non-UV irradiated modified, and non-modified acrylic resins were evaluated using the estimation of planktonic cell count and biofilm formation of the three microorganisms mentioned above. The data were analysed by one-way analysis of variance (ANOVA), followed by a post-hoc Tukey’s test at a significance level of 5%. MIC, for Streptococcus. mutans, Lactobacillus. acidophilus, and Candida. albicans, MBC for S. mutans and L. acidophilus and MFC for Candida. albicans were obtained more than 2100 µg/mL. The results of this study indicated a significant reduction in both planktonic cell count and biofilm formation of modified UV-activated acrylic specimens compared with the control group (p = 0.00). According to the results of the current study, it can be concluded that PMMA/ TiO2 nanotube composite can be considered as a promising new material for antimicrobial approaches. © 2018, Iranian Journal of Pharmaceutical Research. All rights reserved.