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Correlation Between Interleukin-28 Gene Polymorphism With Interleukin-28 Cytokine Levels and Viral Genotypes Among Hcv Patients in Yazd, Iran Publisher Pubmed



Moghimi M1 ; Tavakoli F2 ; Doosti M3, 4 ; Ahmadivasmehjani A2 ; Akhondimeybodi M5
Authors

Source: BMC Research Notes Published:2019


Abstract

Objectives: Recent studies using genome-wide association studies (GWAS) have shown the strong association between polymorphisms near the interleukin-28B (IL-28B) gene and spontaneous clearance of hepatitis C virus (HCV). The present study was designed to evaluate the association of interleukin-28 gene polymorphism with interleukin-28 cytokine levels in different viral genotypes among HCV patients in Yazd, Iran. Result: The most prevalent genotype in chronic cases was genotype 3a, and the lowest one was 2/3a. There were statistically significant differences in genotype frequency between the two studied groups for IL-28B rs12979860C/T. The frequency of CC genotype of IL-28B at rs12979860 SNP was higher in spontaneously cleared patients in comparison with chronic HCV patients. Significant association was found when serum levels of IL28B were compared to various IL-28 genotypes. There was a significant difference between IL-28 polymorphism and HCV genotypes (p = 0.003). © 2019 The Author(s).
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