Exosomes: Potential Player in Endothelial Dysfunction in Cardiovascular Disease Publisher Pubmed



Nikdoust F¹ ; Pazoki M² ; Mohammadtaghizadeh M³ ; Aghaali MK⁴ ; Amrovani M⁵
Source: Cardiovascular Toxicology Published:2022

Abstract

Exosomes are spherical bilayer membrane vesicles with an average diameter of 40–100 nm. These particles perform a wide range of biological activities due to their contents, including proteins, nucleic acids, lipids, lncRNA, and miRNA. Exosomes are involved in inflammation induction, oxidative stress and apoptosis, which can be effective in endothelial dysfunction. Due to the induction of mentioned processes in the endothelial cells, the intercellular connections are destroyed, cell permeability increases and finally cell efficiency decreases and functional defects occur. Cardiovascular disease (CVDs) are of consequences of endothelial dysfunction. Thus by identifying the exosome signaling pathways, which induce inflammation, oxidative stress, and apoptosis, endothelial dysfunction and subsequently CVDs can be reduced; exosomes can be used for appropriate target therapy. © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.