Therapeutic Potential of Apoptotic Vesicles in Modulating Inflammation, Immune Responses, and Tissue Regeneration Publisher Pubmed

Summary: Dead cells healing? Review on ApoEVs for cancer apoptosis, anti-inflammation via efferocytosis. Study suggests versatile therapy for diabetes, OA. Recycle for health? #ApoptoticVesicles #RegenerativeMedicine

Khalilzad MA^{1, 2, 3} ; Mohammadi J¹ ; Amirsaadat S⁴ ; Najafi S^{5, 6} ; Zare S^{2, 7, 8, 9} ; Nilforoushzadeh MA^{2, 10} ; Khalilzad M¹¹ ; Amirkhani MA² ; Peyrovan A² ; Khalili SFS² ; Farahani A^{12, 13} ; Zare S^{2, 7, 8, 9}
Source: Journal of Nanobiotechnology Published:2025

Abstract

The process of apoptosis plays a crucial role in tissue homeostasis, immune system regulation, and organ formation. Apoptotic vesicles (ApoEVs) are involved in efferocytosis, the process by which phagocytes ingest dead cells. ApoEVs also have potential therapeutic applications in cancer treatment, ischemic diseases, and their anti-inflammatory properties make them incredibly versatile for medical applications. These vesicles can induce apoptosis in cancer cells, provide tumor antigens for cancer vaccines, and even serve as effective drug delivery systems. Moreover, they can target hypoxic cells, inhibit inflammatory cell death pathways, and promote tissue regeneration. Also, their potential in addressing inflammatory disorders such as gastrointestinal ailments, osteoarthritis, and diabetes is promising. Additionally, ApoEVs can polarize anti-inflammatory immune cells and suppress inflammatory immune responses which make them a viable option for addressing the unmet need for novel anti-inflammatory medications. Despite a wealth of reviews examining the applications of ApoEVs, very few have thoroughly investigated the mechanisms underlying their anti-inflammatory effects. This distinctive approach positions the current review as timely and immensely relevant, illuminating the intriguing ways these entities function beyond their established advantages. © The Author(s) 2025.