Tehran University of Medical Sciences

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Conjugated Anionic Peg-Citrate G2 Dendrimer With Multi-Epitopic Hiv-1 Vaccine Candidate Enhance the Cellular Immune Responses in Mice Publisher Pubmed



Abdoli A1 ; Radmehr N2 ; Bolhassani A1 ; Eidi A2 ; Mehrbod P3 ; Motevalli F1 ; Kianmehr Z4 ; Chiani M5 ; Mahdavi M6 ; Yazdani S7 ; Ardestani MS8 ; Kandi MR9 ; Aghasadeghi MR1
Authors

Source: Artificial Cells# Nanomedicine and Biotechnology Published:2017


Abstract

Multi-epitope vaccines might cause immunity against multiple antigenic targets. Four immunodominant epitopes of HIV-1 genome were used to construct a polytope vaccine, formulated by dendrimer. Two regimens of polytopes mixture with dendrimer were utilized to immunize BALB/c mice. Adjuvants were also used to boost immune responses. The conjugated polytope could arouse significant cellular immune responses (P < 0.05) and Th1 response showed higher intensity compared to Th2 (P < 0.05). Our study depicted that conjugated dendrimer with multi-epitopic rHIVtop4 would efficiently induce cell-mediated immune responses and might be considered as promising delivery system for vaccines formulation. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
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