Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Serum Ghrelin Levels and Gender-Related Indices of Body Composition in Prepubertal Children: A Cross-Sectional Study Publisher Pubmed



Bagheri M1 ; Ansari S2 ; Sotoudeh G1 ; Mahmoudi M3 ; Speakman JR4, 5 ; Djafarian K2
Authors

Source: European Journal of Nutrition Published:2015


Abstract

Background: A wide variety of functions has been attributed to ghrelin, a peptide hormone secreted in the stomach. The objective of the study was to assess the association of ghrelin concentrations with body composition among Iranian children. Methods: In this study, blood samples of 57 boys and 54 girls aged 6–10 were collected to measure ghrelin levels. Fat mass (FM) and fat-free mass (FFM) were examined by body composition analyzer. Actigraph GT3X was administered to assess children’s physical activity and sleep. Data were analyzed using linear regression models. Results: All measured parameters did not differ between genders except for sleep time which was higher and sleep efficacy which was lower in boys compared with girls. None of the FM and FFM indices studied in boys was significantly associated with ghrelin levels. In girls, however, ghrelin concentrations were significantly associated with FM (β = 0.04, P = 0.01), fat mass index (β = 0.07, P = 0.008), and fat-free mass index (β = 0.08, P = 0.04) and near-significantly associated with FFM (β = 0.03, P = 0.09) after adjusting for age, physical activity, sleep, and dietary intake. Conclusion: Girls with higher ghrelin levels were more likely to have increased total FM and FFM. Conversely, body composition was not associated with ghrelin levels in boys. Consequently, ghrelin may influence the gender-related differences of body composition during childhood in girls. But, further study is needed to confirm our findings. © 2014, Springer-Verlag Berlin Heidelberg.
Related Docs
View other Related Docs
1. An Evaluation of Acylated Ghrelin and Obestatin Levels in Childhood Obesity and Their Association With Insulin Resistance, Metabolic Syndrome, and Oxidative Stress, Journal of Clinical Medicine (2016)
2. The Association Between Body Composition and Level of Leptin in Serum Among Aged 6-10 Yr Old Tehranian Students, Iranian Journal of Endocrinology and Metabolism (2015)
3. Acylated Ghrelin Increases During Military Training in Lean Males, Asian Journal of Sports Medicine (2017)
Experts (# of related papers)
View all Related Experts
Hamideh Pishva (3)
Kurosh Djafarian (2)
Other Related Docs
4. The Association of Appetite and Hormones (Leptin, Ghrelin, and Insulin) With Resting Metabolic Rate in Overweight/ Obese Women: A Case–Control Study, BMC Nutrition (2022)
5. Total and Acylated Ghrelin Levels in Children and Adolescents With Idiopathic Short Stature and Poor Appetite, Acta Endocrinologica (2015)
6. Consumption of Vitamin D-Fortified Yogurt Drink Increased Leptin and Ghrelin Levels But Reduced Leptin to Ghrelin Ratio in Type 2 Diabetes Patients: A Single Blind Randomized Controlled Trial, European Journal of Nutrition (2017)
7. Relationship Between Estrogen and Body Composition, Energy, and Endocrine Factors in Obese Women With Normal and Low Ree, Steroids (2018)
8. Acylated Ghrelin, Growth Hormone and Igf-1 Levels in the Cord Blood of Small for Gestational Age Newborns, Journal of Comprehensive Pediatrics (2016)
9. Association Between Clock 3111 T/C Polymorphism With Ghrelin, Glp-1, Food Timing, Sleep and Chronotype in Overweight and Obese Iranian Adults, BMC Endocrine Disorders (2022)
10. Ucp2, Shbg, Leptin, and T3 Levels Are Associated With Resting Energy Expenditure in Obese Women, Endocrine# Metabolic and Immune Disorders - Drug Targets (2020)
11. Apoa2 −256T>C Polymorphism Interacts With Saturated Fatty Acids Intake to Affect Anthropometric and Hormonal Variables in Type 2 Diabetic Patients, Genes and Nutrition (2015)
12. The Comparison of Chemerin, Adiponectin and Lipid Profile Indices in Obese and Non-Obese Adolescents, Diabetes and Metabolic Syndrome: Clinical Research and Reviews (2016)
13. Association of Short Stature and Obesity With Cardio-Metabolic Risk Factors in Iranian Children and Adolescents: The Caspian-V Study, Journal of Diabetes and Metabolic Disorders (2021)
14. Prevalence of Acanthosis Nigricans and Related Factors in Iranian Obese Children, Journal of Clinical and Diagnostic Research (2017)
15. The Association of Dietary Choline and Betaine and Anthropometric Measurements Among Iranian Children: A Cross-Sectional Study, BMC Pediatrics (2021)
16. Effect of Continuous Positive Airway Pressure on Changes of Plasma/Serum Ghrelin and Evaluation of These Changes Between Adults With Obstructive Sleep Apnea and Controls: A Meta-Analysis, Life (2023)
17. Chronotype-Specific Associations of Meal Timing Patterns With Cardiometabolic Health in Women: A Cross-Sectional Study, Nutrition and Metabolism (2025)
18. The Association Between Dietary Glycemic Index and Cardio-Metabolic Risk Factors in Obese Individuals, BMC Nutrition (2022)
19. Role of Rs9939506 Polymorphism of Fto Gene in Resistance to Eating in Male Adolescents, BMC Pediatrics (2023)
20. The Mediating Role of Obesity in the Associations of Meal-Specific Dietary Patterns and Chrono-Nutrition Components With Cardiometabolic Risk Factors: Structural Equation Modeling, Nutrition and Metabolism (2024)