Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
In-Vitro Antibacterial Evaluation of Some Fluoroquinolone Derivatives Against Food Borne Bacteria



Shariatifar N1 ; Rezaei M1 ; Sayadi M1 ; Moshafi MH2 ; Saeedi M3, 4 ; Mohammadhosseini N5 ; Moghimi S5 ; Foroumadi A5
Authors

Source: Journal of Sciences# Islamic Republic of Iran Published:2016

Abstract

Food poisoning has been emerged as a worldwide health issue and related illness in both developed and developing countries confirms its significance as an important public health priority. In vitro antibacterial evaluation of nine fluoroquinolone derivatives against food borne bacteria including Gram-positive (Staphylococcus aureus) and Gram-negative (Salmonella enterica, Escherichia coli, Yersinia enterocolitica, Vibrio cholerae) organisms was developed using agar dilution technique and compared with ciprofloxacin and norfloxacin as reference drugs. Most compounds showed good activity against Gram-positive and the Gram-negative bacteria. All compounds were active against Staphylococcus aureus (MIC=3.12-6.12μg/mL) and compounds 1a, 1c-e, 2a, and 3c (MIC=3.12μpg/mL) exhibited excellent antibacterial activity in comparison to ciprofloxacin and norfloxacin (MIC=6.25μg/mL). Fluoroquinolone derivatives exhibited good activity against food borne bacteria and are appropriate candidates for food poisoning prevention.
Related Docs
View other Related Docs
1. Novel Levofloxacin Derivatives As Potent Antibacterial Agents, Journal of Sciences# Islamic Republic of Iran (2017)
2. New 7-Piperazinylquinolones Containing (Benzo[D]Imidazol-2-Yl)Methyl Moiety As Potent Antibacterial Agents, Molecular Diversity (2018)
3. N-Substituted Piperazinyl Sarafloxacin Derivatives: Synthesis and in Vitro Antibacterial Evaluation, DARU# Journal of Pharmaceutical Sciences (2018)
Experts (# of related papers)
View all Related Experts
Alireza Foroumadi (6)
Nasrin Samadi (4)
Other Related Docs
4. Biology-Oriented Drug Synthesis (Biods) Approach Towards Synthesis of Ciprofloxacin-Dithiocarbamate Hybrids and Their Antibacterial Potential Both in Vitro and in Silico, Chemistry and Biodiversity (2018)
5. Design and Synthesis of New N-Thioacylated Ciprofloxacin Derivatives As Urease Inhibitors With Potential Antibacterial Activity, Scientific Reports (2022)
6. Novel Fluoroquinolones Analogues Bearing 4-(Arylcarbamoyl)Benzyl: Design, Synthesis, and Antibacterial Evaluation, Molecular Diversity (2023)
7. New Ciprofloxacin–Dithiocarbamate–Benzyl Hybrids: Design, Synthesis, Antibacterial Evaluation, and Molecular Modeling Studies, Research on Chemical Intermediates (2019)
8. Design, Synthesis, Molecular Docking Study, and Antibacterial Evaluation of Some New Fluoroquinolone Analogues Bearing a Quinazolinone Moiety, DARU# Journal of Pharmaceutical Sciences (2020)
9. Antibacterial Activity of Gold Nanoparticles Conjugated by Aminoglycosides Against A. Baumannii Isolates From Burn Patients, Recent Patents on Anti-Infective Drug Discovery (2018)
10. Mechanism of Action and Application of Virocids in Health Careassociated Viral Infections, Tehran University Medical Journal (2016)
11. Antibacterial, Antifungal and Antioxidant Activities of Bee Glue Ethanol and Aqueous Extracts, Journal of Biological Research (Italy) (2017)
12. In Vitro Antimicrobial and Acetylcholinesterase Inhibitory Activities of Coumarins From Ferulago Carduchorum, Medicinal Chemistry Research (2016)
13. Thymol and Carvacrol Against Klebsiella: Anti-Bacterial, Anti-Biofilm, and Synergistic Activities—A Systematic Review, Frontiers in Pharmacology (2024)
14. New Coumarin Derivatives From Ferula Pseudalliacea With Antibacterial Activity, Natural Product Research (2016)
15. Detection of Fluoroquinolone Genes and Spread of Antibiotic Resistance Profile of Enterococcus Strains Isolated From Clinical Specimens, Gene Reports (2020)
16. Synthesis of New 2-(5-(5-Nitrofuran-2-Yl)-1,3,4-Thiadiazol-2-Ylimino)Thiazolidin-4-One Derivatives As Anti-Mrsa and Anti-H. Pylori Agents, BMC Chemistry (2022)
17. A Single Key for Many Doors? Unlocking the Bio-Chemical Potential of Lactobacillus Bulgaricus Metabolic Postbiotic, Probiotics and Antimicrobial Proteins (2025)
18. Antibacterial Activity of Silver Nanoparticles and Their Combination With Zataria Multiflora Essential Oil and Methanol Extract, Jundishapur Journal of Microbiology (2016)
19. Investigation of Peppermint (Mentha Piperita) Extract on the Inhibition of Biofilm Formation by Acinetobacter Baumannii Strains Isolated From Clinical Samples, Iranian Journal of Pharmaceutical Research (2025)
20. Increased Antibacterial Activity of Cinnamon Oil Microemulsionin Comparison With Cinnamon Oil Bulk and Nanoemulsion, Nanomedicine Research Journal (2018)