The Risk of the Next Child Getting Affected by Chronic Granulomatous Disease in Families With at Least One Autosomal Recessive Cgd Child Publisher Pubmed



Modarresi SZ^{1, 2} ; Tajik S¹ ; Badalzadeh M¹ ; Fazlollahi MR¹ ; Houshmand M³ ; Maddah M¹ ; Alizadeh Z¹ ; Nabavi M⁴ ; Bazargan N⁵ ; Movahedi M^{1, 6} ; Pourpak Z¹
Source: Iranian Journal of Allergy# Asthma and Immunology Published:2023

Abstract

Chronic granulomatous disease (CGD) is a rare primary immunodeficiency disorder more common in autosomal recessive (AR) than X-linked in Iran. This study aimed to assess whether having a child with AR-CGD would increase the likelihood of the next child being affected by CGD. Ninety-one families with at least one child affected by AR-CGD entered this study. Out of the 270 children, 128 were affected by AR-CGD. We used a cross tab for the odds ratio (OR) calculation, in which exposure to a previously affected child and the next child’s status were evaluated. This study illustrated that the chances of having another child afflicted with AR-CGD are significantly increased if the previous child had AR-CGD (OR=2.77, 95% CI=1.35-5.69). Although AR disorders affect 25% of each pregnancy, we showed that the chance that the next child would be affected by CGD, given that the previous child was affected, is 2.77 times greater than in families with a normal child. It is recommended to warn families with one or more affected children to evaluate the risk of CGD in their subsequent pregnancies with prenatal diagnosis. Copyright © 2023 Modarresi et al. Published by Tehran University of Medical Sciences.