Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Determination of Morphine and Its Metabolites in the Biological Samples: An Updated Review Publisher Pubmed



Amini R1, 2 ; Rahimpour E1, 3 ; Jouyban A1, 4
Authors

Source: Bioanalysis Published:2020


Abstract

Morphine (MO) as an opioid analgesic is used for the treatment of moderate-to-severe pains, particularly cancer-related pains. Pharmacologic studies on MO are complicated due to drugs binding to the protein or metabolization to active metabolites, and even inter-individual variability. This necessitates the selection of a reliable analytical method for monitoring MO and the concentrations of its metabolites in the biological samples for the pharmacokinetic or pharmacodynamic investigations. Therefore, this study was conducted to review all the analytical research carried out on MO and its metabolites in the biological samples during 2007-2019 as an update to the study by Bosch et al. (2007). © 2020 Future Medicine Ltd.. All rights reserved.
Other Related Docs
5. A Nationwide Study on Consumption of Opioid Analgesics in Iran From 2000 to 2018, International Journal of Clinical Pharmacy (2023)
13. Overexpression of Adiponectin Receptors in Opium Users With and Without Cancer, Clinical Pharmacology: Advances and Applications (2020)
20. Mumijo Attenuates Chemically Induced Inflammatory Pain in Mice, Alternative Therapies in Health and Medicine (2015)