Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
Assessment of Post-Radiation Time Effect on Gene Expression Profiles of Saccharomyces Cerevisiae Samples After Appling a Uv Laser Publisher



Arjmand B1 ; Safarialighiarloo N2 ; Razzaghi M3 ; Tavirani MR4 ; Nejad MR5 ; Tavirani MR4
Authors

Source: Journal of Lasers in Medical Sciences Published:2021


Abstract

Introduction: Widespread application of lasers in different fields of medicine implies more investigations into the molecular mechanism of laser effects on the human body. Network analysis of the dysregulated genes of Saccharomyces cerevisiae samples are irradiated by a UV laser and harvested 30 minutes after radiation compared with a 15-minute group is the aim of this research. Methods: The significant dysregulated genes interacted via the STRING database, and the central nodes were determined by “Networkanalyzer” application of Cytoscape software. The critical genes and the related biological terms were identified via action map analysis and gene ontology assessment.Results: The gene expression profiles of the samples with 30-minute post-radiation time were different from the samples with 15 minutes of post-radiation time. 9 potent central genes, 50% of which were similar to the nodes of the 15-minute group, were identified. The terms “positive regulation of telomere maintenance” were targeted in the two sample groups.Conclusion: In spite of large alteration in the gene expression profiles of the samples, the results indicated that the main affected biological term for the 15-minute and 30-minute groups was similar. © 2021. Journal of Lasers in Medical Sciences. All Rights Reserved.
Other Related Docs
7. Evaluation of Laser Intensity Effect on Photodynamic Therapy Efficacy, Journal of Lasers in Medical Sciences (2024)
9. Evaluation of Efficacy of Low-Level Laser Therapy, Journal of Lasers in Medical Sciences (2020)
12. Introducing Bdnf and Snai1 As the Crucial Targeted Genes by Uv Radiation, Journal of Lasers in Medical Sciences (2022)
14. Gene Activation As a Cell Protection Mechanism Against Gamma-Ray Radiation, Journal of Lasers in Medical Sciences (2020)
18. Low-Level Laser Therapy: Potential and Complications, Journal of Lasers in Medical Sciences (2021)