Recent Progress in Plga-Based Microneedle-Mediated Transdermal Drug and Vaccine Delivery

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Recent Progress in Plga-Based Microneedle-Mediated Transdermal Drug and Vaccine Delivery Publisher Pubmed

Malekkhatabi A¹ ; Sadat Razavi M^{3, 5} ; Abdollahi A¹ ; Rahimzadeghan M⁴ ; Moammeri F⁷ ; Sheikhi M⁶ ; Tavakoli M⁵ ; Radmalekshahi M¹ ; Faraji Rad Z²

Source: Biomaterials Science Published:2023

Abstract

Microneedles (MNs) have recently been found to have applications in drug, vitamin, protein and vaccine delivery. Polymeric MN arrays continue to attract increasing attention due to their capability to bypass the skin's stratum corneum (SC) barrier with minimal invasiveness. These carriers can achieve the targeted intradermal delivery of drugs and vaccines and improve their transdermal delivery level. As a nontoxic FDA-approved copolymer, polylactic glycolic acid (PLGA) has good biocompatibility and biodegradability. Currently, PLGA-based MNs have a noticeable tendency to be utilized as a delivery system. This study focuses on the most recent advances in PLGA-based MNs. Both PLGA nanoparticle-based MNs and PLGA matrix-based MNs, created for the delivery of vaccines, drugs, proteins and other therapeutic agents, are discussed. The paper also discusses the various types of MNs and their potential applications. Finally, the prospects and challenges of PLGA-based MNs are reviewed. © 2023 The Royal Society of Chemistry.

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Style	Citing Format
MLA	Malekkhatabi A, et al.. "Recent Progress in Plga-Based Microneedle-Mediated Transdermal Drug and Vaccine Delivery." Biomaterials Science, vol. 11, no. 16, 2023, pp. 5390-5409.
APA	Malekkhatabi A, Sadat Razavi M, Abdollahi A, Rahimzadeghan M, Moammeri F, Sheikhi M, Tavakoli M, Radmalekshahi M, Faraji Rad Z (2023). Recent Progress in Plga-Based Microneedle-Mediated Transdermal Drug and Vaccine Delivery. Biomaterials Science, 11(16), 5390-5409.
Chicago	Malekkhatabi A, Sadat Razavi M, Abdollahi A, Rahimzadeghan M, Moammeri F, Sheikhi M, Tavakoli M, Radmalekshahi M, Faraji Rad Z. "Recent Progress in Plga-Based Microneedle-Mediated Transdermal Drug and Vaccine Delivery." Biomaterials Science 11, no. 16 (2023): 5390-5409.
Harvard	Malekkhatabi A et al. (2023) 'Recent Progress in Plga-Based Microneedle-Mediated Transdermal Drug and Vaccine Delivery', Biomaterials Science, 11(16), pp. 5390-5409.
Vancouver	Malekkhatabi A, Sadat Razavi M, Abdollahi A, Rahimzadeghan M, Moammeri F, Sheikhi M, et al.. Recent Progress in Plga-Based Microneedle-Mediated Transdermal Drug and Vaccine Delivery. Biomaterials Science. 2023;11(16):5390-5409.
BibTex	@article{ author = {Malekkhatabi A and Sadat Razavi M and Abdollahi A and Rahimzadeghan M and Moammeri F and Sheikhi M and Tavakoli M and Radmalekshahi M and Faraji Rad Z}, title = {Recent Progress in Plga-Based Microneedle-Mediated Transdermal Drug and Vaccine Delivery}, journal = {Biomaterials Science}, volume = {11}, number = {16}, pages = {5390-5409}, year = {2023} }
RIS	TY - JOUR AU - Malekkhatabi A AU - Sadat Razavi M AU - Abdollahi A AU - Rahimzadeghan M AU - Moammeri F AU - Sheikhi M AU - Tavakoli M AU - Radmalekshahi M AU - Faraji Rad Z TI - Recent Progress in Plga-Based Microneedle-Mediated Transdermal Drug and Vaccine Delivery JO - Biomaterials Science VL - 11 IS - 16 SP - 5390 EP - 5409 PY - 2023 ER -

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