The Association Between Resting Metabolic Rate and Metabolic Syndrome May Be Mediated by Adipokines in Overweight and Obese Women Publisher Pubmed



Sepandar F^{1, 2} ; Rashidbeygi E² ; Maghbooli Z³ ; Khorraminezhad L² ; Hajizadehoghaz M⁴ ; Mirzaei K²
Source: Diabetes and Metabolic Syndrome: Clinical Research and Reviews Published:2019

Abstract

Aims: Adipokines play a major role in developing metabolic syndrome (MetS), and it has been found that there is a significant relationship between MetS and resting metabolic rate (RMR) in obese people. The present study aimed to investigate the mediatory effect of adipokines on the RMR-MetS relationship. Methods: This cross-sectional study included 263 obese and overweight women, mean BMI 33.28 (4.93) kg/m, and mean age 39.02 (11.60) who were assessed for RMR using indirect calorimetry. Moreover, using the body composition analyzer the Body composition was measured. Also, Enzyme-linked Immunosorbent Assay (ELISA) test provided a quantitative measurement of biochemical parameters. Results: The results indicated that women in low RMR group had higher fat mass (P < 0.0001), FFM (P = 0.002), weight (P = 0.006), BMI (P < 0.0001), age (P = 0.01), and hs-CRP (P = 0.001). The results did not confirm any significant mediating roles for RBP4 (P = 0.051, β = −0.28) and Vaspin (P = 0.06, β = 0.32) in the RMR-MetS relationship. Additionally, after a binary regression test, Omentin-1 showed a significant mediating role (P = 0.25, β = 0.04) as an interrelated agent to RMR and MetS. Conclusion: As this study shows, Omentin-1 was found to play a significant mediating role as a mediatory agent in relationship between RMR and MetS. © 2018