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Preclinical and Clinical Applications of Photobiomodulation Therapy in Sperm Motility: A Narrative Review Publisher



Poorhassan M1 ; Gholaminejhad M2 ; Ahmadi H3 ; Mehboudi L4 ; Kameh MC5 ; Pirani M3 ; Hassanzadeh G2, 6
Authors

Source: Journal of Lasers in Medical Sciences Published:2022


Abstract

About 50% of infertility problems are related to male factors and reduced sperm motility. The important factor that affects the structure and function of sperm is reactive oxygen species (ROS), and over-concentration of ROS reduces the quality and motility of sperm. Photobiomodulation therapy (PBMT) using red to near-infrared (NIR) light is useful in oxidative stress restoration. It plays a therapeutic role in disorders such as asthenospermia, oligospermia cases, and cryopreserved sperm. It also enhances the metabolic capacity of sperm and increases the low-level and non-harmful intracellular content of Ca2 +, nitric oxide (NO), and ROS in the stressed cells. Likewise, it modulates survival intracellular pathways and maintains the motility, viability, DNA, and acrosome integrity of sperm. This article reviews the state-of-the-art preclinical and clinical evidence regarding the efficacy of semen PBMT © 2022, Journal of Lasers in Medical Sciences.All Rights Reserved.
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