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Electrochemical Sensing Platform Based on Graphene Oxide-Chitosan for Simultaneous Determination of Some Antihypertensive Drugs Publisher



Nabizadeh H1, 2 ; Feyzi B3 ; Ahmad Salarian A1 ; Reza Abtahi S4 ; Mohammadi A2, 3 ; Hami Z1
Authors

Source: Electroanalysis Published:2023


Abstract

The development of selective and simple methods for the determination of different analytes is of great interest. This is the first time to show the applicability of graphene oxide-chitosan (GO-CS) nanocomposite for designing an electrochemical nanosensor for determination of Amlodipine, Valsartan, and Hydrochlorothiazide, simultaneously. Differential pulse voltammetrics current of AML, HCT, and VAL increased linearly in the ranges of 0.1–110, 0.1–110, and 1–230 μM with LOD of 5.5×10−2, 3.5×10−2 and 8.6×10−2 μM, respectively. Finally, GO-CS/GCE was used for the detection of these drugs in commercial tablets and compared with the reference method (HPLC). © 2022 Wiley-VCH GmbH.
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