Association of Il-10-1082G>A,-819C>T And-592C>A Polymorphisms With Susceptibility to Asthma in Children: A Systematic Review and Meta-Analysis Publisher Pubmed



Dastgheib SA¹ ; Aarafi H² ; Bahrami R³ ; Safa A⁴ ; Khosravibonjar A⁴ ; Hashemzehi A⁵ ; Noorishadkam M⁶ ; Mirjalili SR⁶ ; Salari S⁷ ; Neamatzadeh H^{6, 8}
Source: European Annals of Allergy and Clinical Immunology Published:2022

Abstract

Studies evaluating the association of Interleukin 10 (IL-10) polymorphisms with risk of pediatric asthma found inconsistent data. Here, we performed a meta-analysis to get a precise estimation of the associations. Relevant studies identified in the PubMed, Scopus, CNKI databases were used to perform a meta-analysis. A total of 23 case-control studies including nine studies with 1298 cases and 1079 controls on IL-10-1082G>A, four studies with 622 cases and 603 controls on-819C>T and ten studies with 1480 case and 1462 controls on-592C>A were selected. Overall, there was no significant association between IL-10 polymorphisms with pediatric asthma risk in global population. When stratified by ethnicity, there was a significant association of IL-10-1082G>A with pediatric asthma in Asians and Chinese. This meta-analysis result revealed that IL-10-1082G>A,-819C>T and-592C>A polymorphisms were not associated with pediatric asthma risk in the global population. © 2022, EDRA S.p.A. All rights reserved.