Assessment of Association Between Hla Alleles and Acquired Aplastic Anemia in Iranian Population Publisher



Taheri M¹ ; Akbari MT² ; Ostadali M^{3, 4} ; Hamidieh AA⁵ ; Fallah H⁶ ; Shadnoush M⁷ ; Arsangjang S⁸ ; Ghafourifard S⁹ ; Sayad A⁶
Source: Ecological Genetics and Genomics Published:2021

Abstract

Aplastic anemia is regarded as an immune-related disorder in which T lymphocytes have a prominent role in destroying bone marrow cells. Previous studies have assessed the role of HLA alleles in development of this disorder. In the current investigation, we genotyped HLA-A/-B/DRB1 alleles in 22 Iranian patients with acquired aplastic anemia and the same number of matched healthy subjects. Frequencies of HLA genotypes were in agreement with the Hardy-Weinberg Equilibrium assumption in aplastic anemia patients and healthy controls. Although some HLA alleles and genotypes were represented with different frequencies between patients and controls, the differences did not reach the level of significance. Thus, we suggest conduction of further studies in larger samples sizes to find whether the observed associations in other populations can be found in Iranian patients as well. © 2020 Elsevier Inc.