The Role of Nrf2 in the Regulation of Periodontitis, Peri-Implantitis, Dentin Infection, and Apical Periodontitis Publisher



M Arabpour MALIHE ; M Zareanshahraki MEHRAN ; Rj Albadr Rafid JIHAD ; Wm Taher Waam MOHAMMED ; Mg Alwan Merriam GHADHANFAR ; Mj Jasem Jawad Mahmood JASEM ; Skg Zade Seied Kaveh GHAFFAR ; H Mushtaq HIBA ; K Ghazanfari KHASHAYAR
Source: Biological Procedures Online Published:2025

Abstract

The most frequent dental infections happen when bacteria enter the pulp and spread to the tissues. Dental caries arise from the dissolution of enamel and dentin by the acidic metabolites of oral streptococci. Dissolution leads to cavitation, which allows oral germs to enter the bloodstream. If left untreated, cavitation develops into bacterial invasion of the dental pulp. Dental plaque, also called dental biofilm, is associated with periodontitis. When the pulp is exposed, significant inflammation and necrotic foci occur as bacteria infect the tissue. Intravascular bacteria were identified in all instances, which may indicate an essential pathway for transmitting the infection via the pulp tissue. Also, bacteria buildup around a dental implant can result in peri-implantitis (PI), harming the adjacent bone and gums. Reactive oxygen species (ROS) are produced in excess when pathogens incite host immunological responses. Furthermore, osteogenic differentiation and bone formation depend on the regulated generation of ROS. Cells have complex antioxidant systems that carefully control the amount of ROS and prevent its harm. This mechanism activates transcription for multiple genes involved in antioxidant and cytoprotective functions through specific DNA sequences called antioxidant response elements (AREs). Nuclear factor erythroid-2-related factor-2 (Nrf2) is vital in safeguarding cells from oxidative and chemical harm by controlling various protective mechanisms. There is a potential preventive impact of Nrf2 on periodontitis. It is crucial to consider the involvement of Nrf2 in oral infectious illnesses to develop a substitute treatment strategy against antibiotic resistance. In this study, we have reviewed the diverse functions of Nrf2 in dental diseases, including periodontitis, PI, dentin, and oral root infections, to create a novel treatment approach. In this oral infection, the potential of various Nrf2 inhibitors was examined. (Figure presented.) © 2025 Elsevier B.V., All rights reserved.