The Evolutionary Genetics of Lactase Persistence in Seven Ethnic Groups Across the Iranian Plateau

The Evolutionary Genetics of Lactase Persistence in Seven Ethnic Groups Across the Iranian Plateau Publisher Pubmed

Charati H^{1, 2} ; Peng MS^{1, 2, 3} ; Chen W⁴ ; Yang XY⁵ ; Jabbari Ori R⁶ ; Aghajanpourmir M^{7, 8} ; Esmailizadeh A^{1, 6} ; Zhang YP^{1, 2, 3, 5, 9}

Source: Human Genomics Published:2019

Abstract

Background: The ability to digest dietary lactose is associated with lactase persistence (LP) in the intestinal lumen in human. The genetic basis of LP has been investigated in many populations in the world. Iran has a long history of pastoralism and the daily consumption of dairy products; thus, we aim to assess how LP has evolved in the Iranian population. We recruited 400 adult individuals from seven Iranian ethnic groups, from whom we investigated their lactose tolerance and screened the genetic variants in their lactase gene locus. Results: The LP frequency distribution ranged from 0 to 29.9% in the seven Iranian ethnic groups with an average value of 9.8%. The variants, − 13910*T and − 22018*A, were significantly associated with LP phenotype in Iranians. We found no evidence of hard selective sweep for − 13910*T and − 22018*A in Persians, the largest ethnic group of Iran. The extremely low frequency of − 13915*G in the Iranian population challenged the view that LP distribution in Iran resulted from the demic diffusion, especially mediated by the spread of Islam, from the Arabian Peninsula. Conclusions: Our results indicate the distribution of LP in seven ethnic groups across the Iranian plateau. Soft selective sweep rather than hard selective sweep played a substantial role in the evolution of LP in Iranian populations. © 2019, The Author(s).

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Ali Akbar Amirzargar (3)

Reza Malekzadeh (2)

Style	Citing Format
MLA	Charati H, et al.. "The Evolutionary Genetics of Lactase Persistence in Seven Ethnic Groups Across the Iranian Plateau." Human Genomics, vol. 13, no. 1, 2019, pp. -.
APA	Charati H, Peng MS, Chen W, Yang XY, Jabbari Ori R, Aghajanpourmir M, Esmailizadeh A, Zhang YP (2019). The Evolutionary Genetics of Lactase Persistence in Seven Ethnic Groups Across the Iranian Plateau. Human Genomics, 13(1), -.
Chicago	Charati H, Peng MS, Chen W, Yang XY, Jabbari Ori R, Aghajanpourmir M, Esmailizadeh A, Zhang YP. "The Evolutionary Genetics of Lactase Persistence in Seven Ethnic Groups Across the Iranian Plateau." Human Genomics 13, no. 1 (2019): -.
Harvard	Charati H et al. (2019) 'The Evolutionary Genetics of Lactase Persistence in Seven Ethnic Groups Across the Iranian Plateau', Human Genomics, 13(1), pp. -.
Vancouver	Charati H, Peng MS, Chen W, Yang XY, Jabbari Ori R, Aghajanpourmir M, et al.. The Evolutionary Genetics of Lactase Persistence in Seven Ethnic Groups Across the Iranian Plateau. Human Genomics. 2019;13(1):-.
BibTex	@article{ author = {Charati H and Peng MS and Chen W and Yang XY and Jabbari Ori R and Aghajanpourmir M and Esmailizadeh A and Zhang YP}, title = {The Evolutionary Genetics of Lactase Persistence in Seven Ethnic Groups Across the Iranian Plateau}, journal = {Human Genomics}, volume = {13}, number = {1}, pages = {-}, year = {2019} }
RIS	TY - JOUR AU - Charati H AU - Peng MS AU - Chen W AU - Yang XY AU - Jabbari Ori R AU - Aghajanpourmir M AU - Esmailizadeh A AU - Zhang YP TI - The Evolutionary Genetics of Lactase Persistence in Seven Ethnic Groups Across the Iranian Plateau JO - Human Genomics VL - 13 IS - 1 SP - EP - PY - 2019 ER -

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