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Encapsulation of the Phmb With Nanoliposome and Attachment to Wound Dressing for Long-Term Antibacterial Activity and Biocompatibility Publisher Pubmed



Ahani E1 ; Montazer M2, 3 ; Mianehro A3 ; Samadi N4 ; Toliyat T5 ; Rad MM6
Authors

Source: World Journal of Microbiology and Biotechnology Published:2024


Abstract

Concentration control of some drug are used commonly however their uncontrolled concentration renders severe side effects. Therefore, it is substantial to come up with innovation release control methods. There is a strong affinity between the phospholipid of nanoliposomes and wool cells which facilitate the diffusion of liposomes into the wool structure. On the other hand, polyhexamethylene biguanide (PHMB) has gained popularity as an antibacterial agent; however, the compound’s cytotoxicity has limited its usefulness. By compounding these facts, this work introduces a novel method for sustained drug release via internalization. In this method, PHMB was detained into nanoliposomes infiltrated the wool to generate an extremely regulated release, which was established using various techniques. SEM pictures demonstrated effective absorption of nanoliposome-encapsulated PHMB within the wool fabric. The developed wound dressing showed a sustained drug release, and consequently, perfect biocompatibility and enduring antibacterial activity. Graphical Abstract: (Figure presented.) © The Author(s), under exclusive licence to Springer Nature B.V. 2024.
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