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276Th Enmc Workshop: Recommendations on Optimal Diagnostic Pathway and Management Strategy for Patients With Acute Rhabdomyolysis Worldwide. 15Th-17Th March 2024, Hoofddorp, the Netherlands Publisher



Kruijt N1 ; Laforet P2, 13 ; Vissing J3, 28 ; Bhai S4, 5 ; Stemmerik MG3, 27 ; Kleefeld F6, 11 ; Voermans NC1 ; Bhai S4, 5 ; Fatehi F8 ; Gupta VA10 ; Ferreiro A9 ; Liewluck T14 ; Lucia A15 ; Mcmahon G16 Show All Authors
Authors
  1. Kruijt N1
  2. Laforet P2, 13
  3. Vissing J3, 28
  4. Bhai S4, 5
  5. Stemmerik MG3, 27
  6. Kleefeld F6, 11
  7. Voermans NC1
  8. Bhai S4, 5
  9. Fatehi F8
  10. Gupta VA10
  11. Ferreiro A9
  12. Liewluck T14
  13. Lucia A15
  14. Mcmahon G16
  15. Oates E17
  16. Oconnor F18
  17. Oldfors A19
  18. Quinlivan R20
  19. Ravenscroft G21
  20. Riazi S22
  21. Roos A23
  22. Rouxbuisson N24
  23. Schoser B25
  24. Siciliano G26

Source: Neuromuscular Disorders Published:2025


Abstract

The 276th ENMC Workshop on rhabdomyolysis brought together 21 experts to address the compelling need for standardized guidelines on the clinical approach of rhabdomyolysis. There was a general agreement that a diagnosis of rhabdomyolysis require that 1) clinical symptoms include severe muscle swelling, weakness and/or myalgia; 2) serum CK-levels exceed 10,000 IU/L in case of exertional, and >5000 IU/L in non-exertional rhabdomyolysis; 3) CK-levels reaching a maximum 1–4 days after the event and normalizing to baseline within 1–2 weeks of rest. In case of an underlying neuromuscular condition, CK-levels should exceed 5–10 times the patient's baseline level. Treatment should be initiated only in case of high risk on acute kidney injury, which can be predicted by the McMahon score. Furthermore, recommendations on performing genetic testing were formulated and the use of the ‘RHABDO’- acronym was generally agreed upon as a tool to aid clinicians in deciding which patients require genetic testing. Moreover, recommendations on follow-up were made, with a particular emphasis on evaluation of physical and psychological sequelae. Patient representatives present during the workshop emphasized the importance of the current recommendations for future clinical guidelines on rhabdomyolysis. © 2025