Tehran University of Medical Sciences

Science Communicator Platform

Share By
Effectiveness of Covid-19 Vaccination on Disease Severity: A Case-Control Study in Southeast Iran Publisher



Mohammadi M ; Golpayegani A ; Mohammadi FD ; Majidpour F ; Hesari E ; Dargahpour M ; Jalali P
Authors

Source: Journal of Occupational Health and Epidemiology Published:2025


Abstract

Background: Given the importance of the effectiveness of vaccination in terms of mitigating the severity of COVID-19 and mortality, knowledge of the effect of the vaccine on the severity of COVID-19 in communities is essential. Thus, the purpose of this study was to ascertain the effect of COVID-19 vaccine on the severity of the COVID-19 in southeastern Iran. Materials and Methods: A case–control study of a total of 1520 adults aged >18 years was conducted in Bam County to assess the association between hospitalizations due to COVID-19 and previous vaccination with existing vaccines (including Sinopharm, AstraZeneca, and CovIran Barkat) in the country. Multinomial logistic regression was employed, and odds ratios (OR) and 95% confidence intervals (CIs) were calculated. Results: After controlling for potential confounders, multinomial logistic regression indicated that COVID-19 vaccination lowered the likelihood of hospitalization for men and women in temporary wards (ORmen=0.22 vs ORwomen=0.34), general wards (ORmen=0.25 vs ORwomen=0.31), and intensive care units (ORmen=0.47 vs ORwomen=0.77) (P<0.001). The odds ratio of hospitalization in all wards diminished for men and women who had received Sinopharm or AstraZeneca and for women who had received the Barkat vaccine, while only a significant difference was detected in the reduction among patients who had received the Sinopharm vaccine (P<0.001). Conclusion: The results revealed that vaccination is related to diminished severity of the disease in the hospital. Thus, efforts to increase the vaccinated population can reduce the severity of COVID-19 and might decreasae the need for intensive care in hospitals. © 2025 The Author(s); Published by Rafsanjan University of Medical Sciences.
Related Docs
View other Related Docs
1. Covid-19 Vaccination in Patients With Inborn Errors of Immunity Reduces Hospitalization and Critical Care Needs Related to Covid-19: A Usidnet Report, Journal of clinical immunology (2024)
2. The Efficacy and Effectiveness of Covid-19 Vaccines in Iran: A Systematic Review and Meta-Analysis, BMC Infectious Diseases (2025)
3. Side Effects of Covid-19 Vaccines Among Iranian Healthcare Workers: A Retrospective Cohort Study, Journal of infection in developing countries (2024)
Experts (# of related papers)
View all Related Experts
Masoud Yunesian (2)
Mohammad Gharagozlou (2)
Other Related Docs
4. Covid-19 Vaccine Hesitancy in Iranian Patients With Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2022)
5. Covid-19 Infection Risk Following Elective Arthroplasty and Surgical Complications in Covid-19-Vaccinated Patients: A Multicenter Comparative Cohort Study, Arthroplasty Today (2022)
6. The Effectiveness of Covid-19 Vaccination in Preventing Hospitalisation and Mortality: A Nationwide Cross-Sectional Study in Iran, Journal of Global Health (2024)
7. Pediatric Asthma and Covid-19 Vaccination: Unveiling Patterns of Hesitancy and Acceptance, Therapeutic Advances in Vaccines and Immunotherapy (2024)
8. The Study of Covid-19 Infection Following Vaccination in Patients With Multiple Sclerosis, Multiple Sclerosis and Related Disorders (2022)
9. Effectiveness of Mass Vaccination for Prevention of Hospitalization, Severe Disease and Death Due to Sars-Cov-2 Omicron Ba.2 Variant; a Case-Population Study, Heliyon (2025)
10. The Effectiveness of Covid-19 Vaccines in Reducing the Incidence, Hospitalization, and Mortality From Covid-19: A Systematic Review and Meta-Analysis, Frontiers in Public Health (2022)
11. Importance of the Covid-19 Vaccine Booster Dose in Protection and Immunity, Vaccines (2022)
12. Investigating the Effect of Covid-19 Vaccination on the Course of Disease and Recurrence of Attacks in Patients With Multiple Sclerosis, Jundishapur Journal of Chronic Disease Care (2025)
13. Comparison of Astrazeneca and Sinopharm Vaccines As Boosters in Protection Against Covid-19 Infection, Biologicals (2023)
14. Immunologic Response, Efficacy, and Safety of Vaccines Against Covid-19 Infection in Healthy and Immunosuppressed Children and Adolescents Aged 2 – 21 Years Old: A Systematic Review and Meta-Analysis, Journal of Clinical Virology (2022)
15. Short-Term Sars-Cov-2 Re-Infection Rate in Vaccinated Health Workers Based on Received Vaccines: A Cross-Sectional Study, Current Respiratory Medicine Reviews (2023)
16. Multiple Sclerosis and Covid-19: A Retrospective Study in Iran, PLoS ONE (2023)
17. Investigating Factors Affecting the Effectiveness of Gardasil 4, Cervarix, and Gardasil 9 Vaccines Considering the Who Regions in Females: A Systematic Review, Cancer Epidemiology (2025)
18. Association Between Influenza Vaccination and Severity of Lung Involvement at Ct Images of the Patients With Covid-19 Infection: An Iranian Retrospective Case-Control Study, Caspian Journal of Internal Medicine (2022)
19. Factors Associated With Covid-19 Vaccine Acceptance and Hesitancy in Children: A Comprehensive Survey, BMC Public Health (2024)
20. Prevalence of Sputnik V Covid-19 Vaccine Side Effects Among Healthcare Workers in a Tertiary Care, Academic Center in Tehran City, Iran, Iranian Journal of Health Sciences (2024)