Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
An Approach to Pharmacological Targets of Pyrrole Family From Medicinal Chemistry Viewpoint Publisher Pubmed



Moghadam ES1, 2, 3 ; Mireskandari K4 ; Abdeljalil R3 ; Amini M1, 2
Authors

Source: Mini-Reviews in Medicinal Chemistry Published:2022


Abstract

Pyrrole is one of the most widely used heterocycles in the pharmaceutical industry. Due to the importance of pyrrole structure in drug design and development, herein, we tried to conduct an extensive review of the bioactive pyrrole-based compounds reported recently. The bioactivity of pyr-role derivatives varies, so in the review, we categorized them based on their direct pharmacologic tar-gets. Therefore, readers are able to find the variety of biological targets for pyrrole-containing compounds easily. This review explains around seventy different biologic targets for pyrrole-based deriva-tives, so it is helpful for medicinal chemists in the design and development of novel bioactive compounds for different diseases. This review presents an extensive, meaningful structure-activity relationship for each reported structure as much as possible. The review focuses on papers published between 2018 and 2020. © 2022 Bentham Science Publishers.
Related Docs
View other Related Docs
1. Synthesis and Biological Evaluation of 12-Aryl-11-Hydroxy-5,6-Dihydropyrrolo[2″,1″:3′,4′]Pyrazino[1′,2′:1,5]Pyrrolo[2,3-D]Pyridazine-8(9H)-One Derivatives As Potential Cytotoxic Agents, ACS Omega (2023)
2. Study on the Interaction of 1,5-Diaryl Pyrrole Derivatives With Αglucosidase; Synthesis, Molecular Docking, and Kinetic Study, Medicinal Chemistry (2021)
3. Pyrimidine-Based Egfr Tk Inhibitors in Targeted Cancer Therapy, European Journal of Medicinal Chemistry (2021)
Experts (# of related papers)
View all Related Experts
Alireza Foroumadi (8)
Mohsen Amini (3)
Other Related Docs
4. Evaluating the Effects of Disubstituted 3-Hydroxy-1H-Pyrrol-2(5H)-One Analog As Novel Tyrosinase Inhibitors, Bioorganic Chemistry (2022)
5. Furo, Pyrano, and Pyrido[2,3-D]Pyrimidines: A Comprehensive Review of Synthesis and Medicinal Applications, ChemistrySelect (2024)
6. Chromone Derivatives Bearing Pyridinium Moiety As Multi-Target-Directed Ligands Against Alzheimer's Disease, Bioorganic Chemistry (2021)
7. Thieno[2,3-B]Pyridine Amines: Synthesis and Evaluation of Tacrine Analogs Against Biological Activities Related to Alzheimer's Disease, Archiv der Pharmazie (2020)
8. Facile One-Pot Four-Component Synthesis of 3,4-Dihydro-2-Pyridone Derivatives: Novel Urease Inhibitor Scaffold, Research in Pharmaceutical Sciences (2017)
9. Novel N,N-Dimethylbarbituric-Pyridinium Derivatives As Potent Urease Inhibitors: Synthesis, in Vitro, and in Silico Studies, Bioorganic Chemistry (2020)
10. Synthesis of 4-Alkylaminoimidazo[1,2-A]Pyridines Linked to Carbamate Moiety As Potent Α-Glucosidase Inhibitors, Molecular Diversity (2021)
11. Novel Quinazolines Bearing 1,3,4-Thiadiazole-Aryl Urea Derivative As Anticancer Agents: Design, Synthesis, Molecular Docking, Dft and Bioactivity Evaluations, BMC Chemistry (2024)
12. Synthesis and Antibacterial Activity of New Chalcones Bearing an Imida-Zo[1,2-A]Pyridine Moiety, Current Chemical Biology (2021)
13. Design, Synthesis and Biological Assessment of New 1-Benzyl-4-((4-Oxoquinazolin-3(4H)-Yl)Methyl) Pyridin-1-Ium Derivatives (Bops) As Potential Dual Inhibitors of Acetylcholinesterase and Butyrylcholinesterase, Heliyon (2021)
14. Green Synthesis and Anticancer Evaluation of Novel Chrysin Hydrazone Derivatives, Polycyclic Aromatic Compounds (2023)
15. Synthesis, Molecular Docking Study, and Cytotoxic Activity of 1,3,5-Triaryl Pyrazole Derivatives, Letters in Drug Design and Discovery (2016)
16. Rhodanine-Pyridinium Derivatives As a New Category of Cholinesterase Inhibitors: Design, Synthesis, in Vitro and in Silico Enzymatic Evaluations, International Journal of Biological Macromolecules (2025)
17. Green and Four-Component Cyclocondensation Synthesis and in Silico Docking of New Polyfunctionalized Pyrrole Derivatives As the Potential Anticholinesterase Agents, Molecular Diversity (2022)
18. 6-Cinnamoyl-4-Arylaminothienopyrimidines As Highly Potent Cytotoxic Agents: Design, Synthesis and Structure-Activity Relationship Studies, European Journal of Medicinal Chemistry (2020)
19. Triarylpyrazole Derivatives As Potent Cytotoxic Agents; Synthesis and Bioactivity Evaluation Pyrazole Derivatives As Anticancer Agent, Drug Research (2021)
20. Synthesis of Some Spiro Indeno[1,2-B]Pyrido[2,3-D]Pyrimidine-5,3′ - Indolines As New Urease Inhibitors, Iranian Journal of Pharmaceutical Research (2016)