Effect of Orlistat on Serum Uric Acid Level in Adults: A Systematic Review and Meta-Analysis of Randomised Controlled Trials Publisher Pubmed



Noori S¹ ; Mirzababaei A¹ ; Amini MR² ; Clark CCT³ ; Mirzaei K¹
Source: International Journal of Clinical Practice Published:2021

Abstract

Objective: Hyperuricemia increases the risk of gout and cardiovascular diseases. Obesity increases the risk of hyperuricemia while weight loss (>5 kg) has been reported to decrease urate. The effects of orlistat on serum uric acid (SUA) are still controversial. The aim of this meta-analysis was to evaluate the influence of orlistat on SUA levels in adults. Methods: Relevant studies, published up to May 2020, were searched systematically through PubMed/Medline, Scopus and Google Scholar. All relevant randomised controlled clinical trials were included. Meta-analysis was performed using random-effect model. Subgroup analysis, sensitivity analysis and meta-regression were also carried out. Results: Overall 7 trials (9 datasets) that enrolled 1786 subjects were included. Orlistat showed in a significant change in SUA level (Difference in means: −17.661 μmol, 95% CI: −31.615 to −3.707, P =.01). A low heterogeneity observed across the studies (I2 = 25.119%). After categorising studies on the basis of duration and sample size, the effect of orlistat on SUA was significant. The results of meta-regression were showed that significant relationships were not found between orlistat and SUA in the duration of intervention. Conclusion: We found a significant reduction in SUA following orlistat therapy in adults. © 2021 John Wiley & Sons Ltd