Seroprevalence of Poliovirus Antibodies Among 7-Month-Old Infants After 4 Doses of Oral Polio Vaccine in Sistan-Va-Baluchestan, Islamic Republic of Iran; [Seroprevalence Des Anticorps Du Poliovirus Chez Des Nourrissons Ages De Sept Mois Apres Quatre Doses Du Vaccin Antipoliomyelitique Oral Dans La Province Du Sistan-Baloutchistan (Republique Islamique D'iran)] Publisher Pubmed



Izadi S¹ ; Shahmahmoodi S² ; Zahraei SM³ ; Dorostkar F² ; Majdzadeh SR²
Source: Eastern Mediterranean Health Journal Published:2015

Abstract

Despite high coverage rates of polio vaccine in the Islamic Republic of Iran, the seroconversion rates of infants may be inadequate. This study measured seroprevalence of antibodies against poliovirus serotypes 1 to 3 (PV1, PV2 and PV3) in 7-month-old infants who had received at least 4 doses of trivalent oral polio vaccine. A serosurvey was conducted in 2010 in rural areas of Chabahar, Sistan-va-Baluchestan province. Using cluster sampling, 72 eligible infants were tested for antibody against the 3 poliovirus serotypes according to WHO guidelines. Antibody titres ≥ 1:10 were considered positive. The seropositive rates for antibody against PV1, PV2 and PV3 were 84.7%, 95.8% and 70.8% respectively. Only 63.9% of participants were seropositive for antibodies against all 3 poliovirus serotypes. Except for PV2, the seroprevalence of antibody against the other 2 poliovirus serotypes, especially PV3, was unsatisfactory. © 2015, World Health Organization. All rights reserved.