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Study of Regulatory Promoter Polymorphism (-248 G>A) of Bax Gene in Patients With Gastric Cancer in the Northern Provinces of Iran



Mirmajidi SH1 ; Najafi M2 ; Mirmajidi ST3 ; Nasrabadi NN4
Authors

Source: Gastroenterology and Hepatology from Bed to Bench Published:2016

Abstract

Aim: The aim of this study is to evaluate the polymorphism in Bax gene and its association with some clinical pathology traits in gastric cancer. Background: Gastric cancer is considered as the fourth most common cancer in the north and northwest of Iran. Bcl2 family has a key role in regulation of apoptosis, and any changes in the expression of Bcl2 lead to cancer. Patients and methods: Blood samples were collected from 100 cases and 89 controls in the northern provinces of Iran to evaluate promoter polymorphism (-248G
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