Pigmented Colloid Milium Associated With Exogenous Ochronosis in a Farmer With Long-Term Exposure to Fertilizers Publisher



Akhyani M¹ ; Hatami P¹ ; Yadegarfar Z¹ ; Ghanadan A^{2, 3}
Source: Journal of Dermatological Case Reports Published:2015

Abstract

Background: Colloid milium is a rare cutaneous deposition disorder characterized by translucent papules developing on sun-exposed regions such as the face, neck and dorsal aspects of the hands and back. Exogenous ochronosis is caused by the accumulation of homogentisic acid resulting from long-term application of certain topical agents. Histology is characterized by yellow-brown pigment deposits in the papillary dermis. Prolonged use of hydroquinone may result in the development of the pigmented form of colloid milium, sometimes in association with ochronosis. Case report: A 53-year-old man presented with a 3-year history of multiple slow spreading pigmented papules on the dorsa of his hands, nose and ears. The patient had a long history of exposure to sun and fertilizers with no history of using hydroquinone bleaching creams. A later biopsy revealed the diagnosis of pigmented colloid milium associated with exogenous ochronosis. Conclusion: UV light damage and long contact with fertilizers may have a role in the development of pigmented colloid milium associated with exogenous ochronosis. © 2015, Specjalisci Dermatolodzy. All rights reserved.