Genetic Factors in Determination of Risk of External Apical Root Resorption: A Concise Review Publisher



Behnaz M¹ ; Jazaeri M² ; Aghandeh P³ ; Taheri M⁴ ; Ghafourifard S⁵
Source: Gene Reports Published:2020

Abstract

External apical root resorption (EARR) is a sequel of orthodontic interventions that leads to impairment of configuration of root apex of the teeth. This condition is regarded as a complex situation caused by several unidentified environmental and intrinsic parameters. About two-third of variation in EARR is expected to be explained by genetic factors. Several studies have assessed the role of genetic variants in conferring risk of post-orthodontic EARR. Two kinds of genetic polymorphisms were the focus of most of investigations: single nucleotide polymorphisms (SNPs) within cytokine coding genes and SNPs within genes involved in the bone remodeling. The rs1800587 and rs1143634 in IL-1A and IL-1B genes have been the mostly assessed SNPs in different populations. Yet, the results of investigations in different populations are not consistent. In the current study, we summarize the results of studies which assessed the contribution of genetic factors in EARR. As genetic factors are involved in conferring risk of EARR, evaluation of these variants prior to establishment of orthodontic treatments might help in identification of at-risk individuals and better follow-up of these patients. © 2020 Elsevier Inc.