Endoscopic Resection of Polypoid Solitary Rectal Ulcer: A Novel First-Line Therapeutic Strategy Using Snare-Assisted Mucosal and Fibrosis Resection

Endoscopic Resection of Polypoid Solitary Rectal Ulcer: A Novel First-Line Therapeutic Strategy Using Snare-Assisted Mucosal and Fibrosis Resection Publisher

Forootan M ; Repici A ; Rajabnia Chenari M ; Karimi MA ; Jahanian A ; Ketabi Moghadam P ; Mohammadi M ; Ghadirzadeh E ; Soudi A ; Paraandavaji E ; Shafiei S ; Reza Zali M ; Tashakoripour M

Source: DEN Open Published:2026

Abstract

Objectives: To propose a novel first-line endoscopic therapy for treating polypoid lesions in solitary rectal ulcer syndrome (P-SRUS), the rarest and most challenging subtype of SRUS, which encompasses various endoscopic findings including mucosal erythema, superficial or deep ulcers, and polypoid lesions. Methods: A prospective, single-arm study was conducted on 56 patients with histologically confirmed SRUS and broad-based polypoid lesions in the rectum and anal canal. These patients were referred to the Department of Motility Disorders of the Lower Gastrointestinal Tract. The lesions were removed using snare-assisted mucosal and fibrosis resection. Patients were monitored for clinical and endoscopic responses at 1, 3, 6, and 12 months post-treatment. Results: The study observed improvement in clinical symptoms, a complete endoscopic response, and the absence of late complications following endoscopic resection. Endoscopic evaluations revealed no recurrence of lesions in the follow-up period. Conclusion: Endoscopic resection using the snare-assisted mucosal and fibrosis resection method appears to be an effective and safe treatment option for polypoid SRUS. (Clinical Trial Registration Number: IRCT20211101052935N2). © 2025 Elsevier B.V., All rights reserved.

Related Docs

1. Solitary Rectal Ulcer Syndrome: A Narrative Review, Middle East Journal of Digestive Diseases (2019)

2. Solitary Rectal Ulcer Syndrome: Addition of Rectal Therapies to Biofeedback Is More Effective Than Biofeedback Alone, Gastroenterology and Hepatology from Bed to Bench (2019)

Experts (# of related papers)

Mohammad Biglari (1)

Anahita Sadeghi (1)

Style	Citing Format
MLA	Forootan M, et al.. "Endoscopic Resection of Polypoid Solitary Rectal Ulcer: A Novel First-Line Therapeutic Strategy Using Snare-Assisted Mucosal and Fibrosis Resection." DEN Open, vol. 6, no. 1, 2026, pp. -.
APA	Forootan M, Repici A, Rajabnia Chenari M, Karimi MA, Jahanian A, Ketabi Moghadam P, Mohammadi M, Ghadirzadeh E, Soudi A, Paraandavaji E, Shafiei S, Reza Zali M, Tashakoripour M (2026). Endoscopic Resection of Polypoid Solitary Rectal Ulcer: A Novel First-Line Therapeutic Strategy Using Snare-Assisted Mucosal and Fibrosis Resection. DEN Open, 6(1), -.
Chicago	Forootan M, Repici A, Rajabnia Chenari M, Karimi MA, Jahanian A, Ketabi Moghadam P, Mohammadi M, et al.. "Endoscopic Resection of Polypoid Solitary Rectal Ulcer: A Novel First-Line Therapeutic Strategy Using Snare-Assisted Mucosal and Fibrosis Resection." DEN Open 6, no. 1 (2026): -.
Harvard	Forootan M et al. (2026) 'Endoscopic Resection of Polypoid Solitary Rectal Ulcer: A Novel First-Line Therapeutic Strategy Using Snare-Assisted Mucosal and Fibrosis Resection', DEN Open, 6(1), pp. -.
Vancouver	Forootan M, Repici A, Rajabnia Chenari M, Karimi MA, Jahanian A, Ketabi Moghadam P, et al.. Endoscopic Resection of Polypoid Solitary Rectal Ulcer: A Novel First-Line Therapeutic Strategy Using Snare-Assisted Mucosal and Fibrosis Resection. DEN Open. 2026;6(1):-.
BibTex	@article{ author = {Forootan M and Repici A and Rajabnia Chenari M and Karimi MA and Jahanian A and Ketabi Moghadam P and Mohammadi M and Ghadirzadeh E and Soudi A and Paraandavaji E and Shafiei S and Reza Zali M and Tashakoripour M}, title = {Endoscopic Resection of Polypoid Solitary Rectal Ulcer: A Novel First-Line Therapeutic Strategy Using Snare-Assisted Mucosal and Fibrosis Resection}, journal = {DEN Open}, volume = {6}, number = {1}, pages = {-}, year = {2026} }
RIS	TY - JOUR AU - Forootan M AU - Repici A AU - Rajabnia Chenari M AU - Karimi MA AU - Jahanian A AU - Ketabi Moghadam P AU - Mohammadi M AU - Ghadirzadeh E AU - Soudi A AU - Paraandavaji E AU - Shafiei S AU - Reza Zali M AU - Tashakoripour M TI - Endoscopic Resection of Polypoid Solitary Rectal Ulcer: A Novel First-Line Therapeutic Strategy Using Snare-Assisted Mucosal and Fibrosis Resection JO - DEN Open VL - 6 IS - 1 SP - EP - PY - 2026 ER -

Science Communicator Platform

Authors

Abstract