Voltammetric Detection of Clopidogrel in Pharmaceuticals Utilizing Electropolymerized O-Aminophenol-Mwcnts Modified Electrode Publisher



Barin SM³ ; Mohammadi A^{3, 4} ; Naeemy A³ ; Darbasizadeh B⁵
Source: Russian Journal of Electrochemistry Published:2023

Abstract

Abstract: In the present study, Clopidogrel (CLP), an anti-platelet drug, was analyzed utilizing electropolymerized o-aminophenol (EpoAP) and multi-walled carbon nanotubes (MWCNTs) modified graphite electrode (GE). The prepared electrode was characterized by Cyclic Voltammetry (CV) and Scanning Electron Microscopy (SEM) techniques. The dependence of peak intensities on pH, scan rate, and MWCNTs amount were further investigated. Electrochemical determination of CLP was evaluated by Differential Pulse Voltammetry (DPV) and CV analysis under optimized working conditions. The calibration curves of CLP obtained in the range of 2.0–75.0 µM by DPV and 50.0–200.0 µM by CV. The limits of detection (LOD) calculated to be 0.50 and 6.6 µM via DPV and CV, respectively. In addition, surface area and coverage of the modified electrode, electron-transfer coefficient, and the diffusion coefficient of CLP were calculated. Finally, the fabricated electrode was proved successfully for quantification of CLP in pharmaceuticals directly, which means it’s not necessary to separate the excipients of the tablets for the analysis, with a mean recovery of 97.49%. © 2023, Pleiades Publishing, Ltd.