Dietary Intake of Copper and Gastric Cancer: A Pooled Analysis Within the Stomach Cancer Pooling (Stop) Project Publisher Pubmed



Sassano M¹ ; Collatuzzo G¹ ; Seyyedsalehi MS¹ ; Pelucchi C² ; Bonzi R² ; Palli D³ ; Ferraroni M² ; Lunet N^{4, 5, 6} ; Morais S^{4, 5, 6} ; Lopezcarrillo L⁷ ; Malekzadeh R⁸ ; Pakseresht M^{8, 9, 10} ; Lopezcervantes M¹¹ ; Ward MH¹² Show All Authors
Source: International Journal of Epidemiology Published:2024

Abstract

Background: Evidence on the potential association between dietary copper intake and gastric cancer (GC) is lacking. Thus, we aimed to evaluate this association within the Stomach cancer Pooling (StoP) Project-an international consortium of epidemiological studies on GC. Methods: Data from five case-control studies within the StoP Project were included (2448 cases, 4350 controls). We estimated adjusted odds ratios (ORs) and 95% CIs for the association between dietary copper intake and GC using multivariable mixed-effects logistic regression models. We also modelled the dose-response relationship between copper intake and GC using a logistic mixed-effects model with fractional polynomial. Results: The OR for the highest quartile of copper intake compared with the lowest one was 0.78 (95% CI: 0.63-0.95; P for trend ¼ 0.013). Results were similar for non-cardia-type (OR: 0.72; 95% CI: 0.57-0.91), intestinal-type (OR: 0.75; 95% CI: 0.56-0.99) and other histological-type GC (OR: 0.65; 95% CI: 0.44-0.96). The dose-response analysis showed a steep decrease in ORs for modest intakes (<1 mg/day), which were subsequently steady for ≤3 mg/day (OR: 0.09; 95% CI: 0.02-0.41) and slowly increased for higher intakes. Conclusions: The findings of our large study suggest that copper intake might be inversely associated with GC, although their confirmation by prospective studies is required. © The Author(s) 2024; all rights reserved. Published by Oxford University Press on behalf of the International Epidemiological Association.