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One-Pot Synthesis of Oxoisoindoline-1,2,3-Triazole Hybrid by a Ugi–Click Reaction Publisher



Akrami S1 ; Firoozpour L2 ; Goligarmroodi F3 ; Moghimi S3 ; Mahdavi M2 ; Zonouzi A1 ; Foroumadi A2, 3, 4
Authors

Source: Synthetic Communications Published:2016


Abstract

1,2,3-Triazole-3-oxoisoindoline-1-carboxamide system was successfully synthesized by using a combination of Ugi and click reactions. This two-step, one-pot synthesis was started by the reaction of 2-formyl benzoic acid, propargyl amine, and cyclohexyl isocyanide in ethanol. The resultant Ugi adduct underwent a copper-catalyzed click reaction, producing the desired products in good yields. © 2016, Copyright © Taylor & Francis Group, LLC.