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Natural Killer Cell-Derived Exosomes for Cancer Immunotherapy: Innovative Therapeutics Art Publisher



Hatami Z1 ; Hashemi ZS2 ; Eftekhary M3 ; Amiri A4 ; Karpisheh V5 ; Nasrollahi K6 ; Jafari R7
Authors

Source: Cancer Cell International Published:2023


Abstract

Chimeric antigen receptor natural killer cells (CAR-NK) promote off-the-shelf cellular therapy for solid tumors and malignancy.However, the development of CAR-NK is due to their immune surveillance uncertainty and cytotoxicity challenge was restricted. Natural killer cell-derived exosome (NK-Exo) combine crucial targeted cellular therapies of NK cell therapies with unique non-toxic Exo as a self-origin shuttle against cancer immunotherapy. This review study covers cytokines, adoptive (autologous and allogenic) NK immunotherapy, stimulatory and regulatory functions, and cell-free derivatives from NK cells. The future path of NK-Exo cytotoxicity and anti-tumor activity with considering non-caspase-independent/dependent apoptosis and Fas/FasL pathway in cancer immunotherapy. Finally, the significance and implication of NK-Exo therapeutics through combination therapy and the development of emerging approaches for the purification and delivery NK-Exo to severe immune and tumor cells and tissues were discussed in detail. © 2023, BioMed Central Ltd., part of Springer Nature.
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