Tehran University of Medical Sciences

Science Communicator Platform

Stay connected! Follow us on X network (Twitter):
Share By
In Vitro and in Vivo Antidiabetic Activity of Tamarix Stricta Boiss.: Role of Autophagy Publisher Pubmed



Bahramsoltani R1, 2 ; Farzaei MH3, 4 ; Sajadimajd S5 ; Iranpanah A3, 6 ; Khazaei M7 ; Pourjabar Z8 ; Hajimahmoodi M8 ; Rahimi R1, 2
Authors

Source: Journal of Ethnopharmacology Published:2021


Abstract

Ethnopharmacological relevance: Type 2 diabetes mellitus (DM) is a complicated metabolic disorder with no definite treatment. Different species of the genus Tamarix (tamarisk) are used by local people to treat DM. Tamarix stricta Boiss. is an endemic species to Iran with several traditional therapeutic uses in Persian Medicine. This study aimed to assess the antidiabetic activity of T. stricta. Materials and methods: Hydroethanolic extract of the plant was prepared and analyzed by High-performance liquid chromatography (HPLC). The protective effect of the extract was evaluated in streptozotocin (STZ)-induced toxicity and markers of autophagy in pancreatic RIN-5F cells. The effect of intragastric 10 or 20 mg/kg of the extract was compared with negative control (water) or positive control (metformin) treatment during four weeks of administration in high-fat diet + STZ-induced DM in Balb/c mice. Results: Results showed the presence of 8.436 mg of gallic acid in each gram of the extract. A significant cytoprotective effect was observed by T. stricta in STZ-induced toxicity in RIN-5F cells, partially due to the modulation of autophagy. Also, animals treated with the extract showed a significant improvement in glycemic and lipid profiles, liver function, and histopathologic features of pancreas and liver compared with the negative control. Conclusion: T. stricta demonstrated beneficial effects in animal model of DM; though, further studies are recommended to confirm the clinical use of this plant in DM. © 2020 Elsevier B.V.
Other Related Docs
13. A Mechanistic Review on Medicinal Plants Used for Diabetes Mellitus in Traditional Persian Medicine, Journal of Evidence-Based Complementary and Alternative Medicine (2017)
18. Therapeutic Medicinal Plants in Traditional Persian Medicine, Therapeutic Medicinal Plants in Traditional Persian Medicine (2024)