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The Effect of Midodrine on Lactate Clearance in Patients With Septic Shock: A Pilot Study Publisher Pubmed



Davoudimonfared E1 ; Mohammadi M2 ; Khoshavi M3 ; Khalili H1
Authors

Source: Journal of Comparative Effectiveness Research Published:2021


Abstract

Background: The effect of midodrine on lactate clearance has not been assessed in critically ill patients yet. Objective: The goal of this study was to assess the effect of adjunctive midodrine therapy on lactate clearance in patients with septic shock. Materials & methods: Patients with septic shock were assigned to receive either adjunctive midodrine 10 mg three-times a day for 5 days (midodrine group = 15 patients) or not (control group = 13 patients). Results: The lactate clearance was significantly faster in the midodrine group than the control group (p = 0.049) with a large effect size (η•p2 = 0.141). Conclusion: When midodrine was added to intravenous vasopressors, it significantly accelerated lactate clearance in patients with septic shock. Trial registration number: IRCT20100228003449N25 (Clinicaltrials.gov). © 2021 Future Medicine Ltd.. All rights reserved.
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