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Genetic of Alzheimer's Disease: A Narrative Review Article



Khanahmadi M1 ; Farhud DD2, 3 ; Malmir M4
Authors

Source: Iranian Journal of Public Health Published:2015

Abstract

Background: Alzheimer's disease (AD) is one of the most common problems for old peoples. Etiology of AD is not clear, but genetic factors play a major role in determining a person's risk to develop AD. Twin and family studies confirm that AD has a genetic basis.AD genetics has been split into two broad categories: early-onset and late-onset. EO-AD cases are inherited in an autosomal dominant pattern. In this form, dominant mutations in genes like APP, PSEN-1 and PSEN-2 associated with AD. This study aimed to consider the role of genetic in AD. Method: At the first, most of the references in relation with genetic basis of AD searched from the following websites: PubMed, Science direct, Wiley & Sons (1995-2014). Then, the most common genes and their affects described briefly. Results: Aging is the most obvious risk factor for developing AD. There is a genetic basis for AD, of course this relation is not complete but it is significant. Conclusion: More than thousand genes studied in relation with Alzheimer's disease. Against the improvements in understanding different aspects of AD, the accurate genetic foundation of AD remain unclear. © 2015 Iranian Journal of Public Health. All Rights Reserved.
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