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Analysis of Amino Acid Changes in Ns Protein of Influenza A/(H3n2) Virus in Iranian Isolates Publisher



Dahiru Rogo L1, 2 ; Rezaei F1, 3 ; Shafieijandaghi NZ1, 3 ; Ghavami N1, 3 ; Fateminasab G1, 3 ; Mokhtariazad T1, 3
Authors

Source: Future Virology Published:2015


Abstract

Aim: Roles of NS gene of influenza A virus in virulence and replication are well established but extent of its variation in seasonal influenza A (H3N2) viruses in Iran is not well known. Materials & methods: NS gene of 37 (A/H3N2) virus isolates were sequenced and analyzed for information on genetic changes. Results: Data analysis of NS1 protein revealed two amino acid substitutions E26K and Q193R in almost all strains. Substitutions in T58P in 27.0%, A86S in 13.5% and each of V11G, M81I and P85T in 2.7% Iranian strains were also observed. Mutations in NS2/NEP protein were observed in K36E, Q101L and F107S. Conclusion: Many mutations were observed for the first time in Iranian strains. Their function remains to be determined. © 2015 Future Medicine Ltd.
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